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Hayriye Cagnan, University of Oxford, UK : Exploring the role of neural synchrony in pathology

MRC Career Development Fellow | Nuffield Department of Clinical Neurosciences | MRC Brain Network Dynamics Unit | University of Oxford | UK
When Feb 23, 2021
from 05:15 PM to 06:00 PM
Where Zoom Meeting. Meeting ID and password will be sent with e-mail invitation.
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Abstract

Our everyday actions, such as the coordination of movement, are thought to involve multiple brain regions, which exchange information through transient neural synchrony. Emerging evidence suggests that a range of neurological disorders, including Parkinson’s disease and Essential Tremor, could be attributed to dysfunction of this fundamental neural property. During these disorders, disease symptoms are strongly correlated with the extent of neural synchrony. Deep brain stimulation is commonly used to reduce disease symptoms by delivering high frequency electrical pulses to key brain regions. When stimulation is effective in suppressing disease symptoms, it has been shown that excessive neural synchrony observed across the motor circuit is also significantly reduced.

I will first describe transient changes that take place across the motor circuit during Parkinson’s disease, and highlight how subcortical neural dynamics are modulated by spontaneous episodes of neural synchrony underlying disease symptoms. I will then present how brain stimulation could be used to probe different disease circuits, and how these insights could be leveraged to develop novel therapies. I will finally present a stimulation strategy called phase-specific brain stimulation, which aims to selectively regulate pathological neural synchrony, and highlight some experimental and theoretical results that show the effect of this stimulation strategy.

 

Zoom Meeting. Meeting ID and password will be sent with the e-mail invitation.
You can also contact Fiona Siegfried for meeting ID and password.

 

About the speaker

Hayriye Cagnan

 

Hosted by

Ad Aertsen

 

Supported by

Carl Zeiss FoundationNeurexNeurex | InterNeuronEU Development FundEU Interreg

 

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