Uni-Logo
You are here: Home News
Document Actions

News

Disentangling the complex signal flow in layered networks of neocortex

Disentangling the complex signal flow in layered networks of neocortex

July 22, 2019: Networks in the brain often have a complex structure, comprising multiple layers or otherwise circumscribed subpopulations of nerve cells. Will it ever be possible to untangle the mind-boggling chatter among neurons that experimenters record in such networks with their highly sophisticated methods? Researchers from Stefan Rotter’s research group at the Bernstein Center Freiburg are now proposing a novel theoretical framework to sort out some of the encountered difficulties. Using the example of a computer simulated network model of layered visual cortex, they are able to show, among other things, how feature selectivity and tuning curves of nerve cells in different layers emerge as a result of system-wide processing. Their work has now been published in the journal PLOS Computational Biology.

Read More…

The focus is on Europe at the 2019 Stallwächterparty

The focus is on Europe at the 2019 Stallwächterparty

July 01, 2019: Inform, explain, answer questions – this was the mission of Stefan Rotter, Managing Director of the Bernstein Center Freiburg (BCF), who travelled to Berlin for the 56th Baden-Württemberg Stallwächterparty. The BCF accepted the invitation of Prof. Dr. Dr. Hans-Jochen Schiewer, Rector of the University of Freiburg and President of Eucor – The European Campus, to represent the trinational university network of the Upper Rhine together with the Karlsruhe Institute of Technology. Stefan Rotter used this opportunity to plead the case for fundamental research to Minister Theresia Bauer, responsible for Universities, Research Institutions and Art Institutions in Baden-Württemberg.

Read More…

Simulating the effect of transcranial brain stimulation

Simulating the effect of transcranial brain stimulation

June 28, 2019: The long-lasting aftereffects of non-invasive transcranial direct current stimulation (tDCS) promise an alleviation of severe symptoms of diseases like depressive disorder or chronic pain. In a new modeling study, researchers from the Bernstein Center Freiburg suggest that the aftereffects observed in experiments may be a consequence of homeostatic network growth. Their model is based on the idea that the stimulation triggers a rearrangement of synaptic couplings among stimulated and unstimulated neurons, eventually leading to network remodeling and cell assembly formation. Their findings have now been published in the journal Network Neuroscience.

Read More…

Six fingers per hand: A congenital additional finger brings motor advantages

Six fingers per hand: A congenital additional finger brings motor advantages

June 03, 2019: Polydactyly is the extraordinary condition of someone being born with more than five fingers or toes. In a case study published today in Nature Communications, researchers from the University of Freiburg, Imperial College London, the University Hospital of Lausanne, and EPFL have for the first time examined the motor skills and sensorimotor brain areas in people with polydactyly. The results show that an extra finger can significantly extend the manipulation abilities and skill.

Read More…

Inhomogeneities in network structure govern spontaneous activity

Inhomogeneities in network structure govern spontaneous activity

May 31, 2019: Networks of biological neurons can be spontaneously active. In absence of sensory input, neurons send and receive action potentials generated by the network itself. The connectivity between neurons is a key factor regulating the generation and propagation of such spontaneous activity but the exact mechanisms are not known and difficult to access in vivo. Researchers from the Bernstein Center Freiburg investigated the origin of spontaneous activity generation in networks of cultured cortical neurons. They found that spontaneous activity mainly originates in regions where such networks are inhomogeneous. Their findings have now been published in Frontiers in Neuroscience.

Read More…

A constant thirst for new knowledge

A constant thirst for new knowledge

May 22, 2019: This was a major reason why Benjamin Merkt decided to write a doctoral thesis. Now he is among those who have successfully completed their dissertation and is pleased that everything turned out so well. Congratulations!

Read More…

Non-invasive Assessment of Superficial and Deep Layer Circuits in Human Motor Cortex

Non-invasive Assessment of Superficial and Deep Layer Circuits in Human Motor Cortex

May 21, 2019: An international collaboration of research teams from the Department of Sport Science Freiburg, the Bernstein Center Freiburg and the Institute of Neuroscience at Newcastle University developed a technique to investigate layer-specific activity modulations in the human motor cortex. The novel approach has now been published in The Journal of Physiology.

Read More…

The theorist with a passion for the practical

The theorist with a passion for the practical

May 08, 2019: Perfect timing for Michael Kordovan – after his excellent doctorate, the young scientist is now taking the step which he had originally planned to take after his diploma studies. He has just signed his work contract with a company for industrial image processing.

Read More…

Outstanding achievement by Ali Mahmoodi

Outstanding achievement by Ali Mahmoodi

April 26, 2019: The Bernstein Center Freiburg would like to congratulate Ali Mahmoodi on his distinguished doctorate on “Behavioural and Neural Basis of Social Influence”.

Read More…

“Working at the Bernstein Center has been a great opportunity for me.”

“Working at the Bernstein Center has been a great opportunity for me.”

April 16, 2019: This is what Mohammadreza Mohagheghi Nejad thinks overall about his time as a PhD student in Freiburg. Now that the biomedical engineer has successfully finished his doctorate, what is going through the mind of the young scientist after graduating? He talked with the Bernstein Center Freiburg about this.

Read More…

Golan Karvat wins Best Paper Award in German Neuroscience Society meeting

Golan Karvat wins Best Paper Award in German Neuroscience Society meeting

April 4, 2019: Golan Karvat, PhD student of the Bernstein Center Freiburg in the Optophysiology lab led by Prof. Dr. Ilka Diester, won the Best Paper Award in the 2019 Göttingen meeting of the German Neuroscience Society. The talk, titled “LFP-burst based real-time neurofeedback in rats”, was presented in the Breaking News symposium, and selected as the best talk according to the criteria: novelty of findings presented, potential impact on future research and the quality of the presentation.

Read More…

Controlling Biological Neuronal Networks with Reinforcement Learning

Controlling Biological Neuronal Networks with Reinforcement Learning

March 7, 2019: It is an important therapeutic strategy for many neurological disorders to influence brain activity by means of deep brain stimulation. However, setting stimulus parameters optimally is a difficult problem and might require constant adaptation. To make stimulation more efficient, an interdisciplinary research team of the Department of Computer Science, the Department of Microsystems Technology (IMTEK) and the Bernstein Center Freiburg proposes a new closed-loop control paradigm based on reinforcement learning and evaluate it on a living model system, namely generic biological neural networks (BNNs) in vitro grown on microelectrode arrays. Their findings have now been published in Neurocomputing.

Read More…

Training Course for Non-academics: Mould a Brain

Training Course for Non-academics: Mould a Brain

January 25, 2019: Dr. Janina Kirsch, biologist and associated member of the Bernstein Center Freiburg, offers a unique training course for non-academics from medical professions.

Read More…

Portraits of Communication in Neuronal Networks | Under which conditions can messages be exchanged?

Portraits of Communication in Neuronal Networks | Under which conditions can messages be exchanged?

December 17, 2018: The brain is organized as a network of highly specialized networks of spiking neurons. An elementary prerequisite for this to work is that groups of neurons in different networks can communicate with each other. Sparse and weak connectivity and high variability of brain activity makes the communication problem highly non-trivial. So the question arises under which conditions can such communication between neuron groups take place?

Read More…

Excellent doctorate for Antje Kilias

Excellent doctorate for Antje Kilias

October 29, 2018: The Bernstein Center Freiburg would like to congratulate Antje Kilias on her excellent dissertation on “Theta Oscillations in a Model of Temporal Lobe Epilepsy”. Now the young biologist is planning the next step in her scientific career and would like to remain true to her topic. The Bernstein Center wishes Antje Kilias all the best for this career planning.

Read More…

Synthetic brain rhythms | Scientists used optogenetic stimulation to induce slow brain rhythms in vivo

Synthetic brain rhythms | Scientists used optogenetic stimulation to induce slow brain rhythms in vivo

August 21, 2018: Researchers from the Bernstein Center Freiburg and the Massachusetts Institute of Technology used an innovative optogenetic stimulation paradigm to evoke synthetic brain rhythms in vivo. In contrast to conventional optogenetic stimulations protocols that rely on light pulses, this protocol employed continuously modulating light intensities to mimic normal brain rhythms using a new implant. These findings have recently been published in Journal of Neural Engineering, and open up possibilities to cell-specifically dissect the neuronal circuits underlying pathological and physiological slow brain oscillations.

Read More…

Taking an electrical fingerprint of nerve cells

Taking an electrical fingerprint of nerve cells

July 16, 2018: Scientists from the Bernstein Center Freiburg and their colleagues from Norway present a framework for the automatized and objective localization and classification of neurons recorded with state-of-the-art high-resolution multi-electrode arrays

Read More…

Generating knowledge and sharing it with society

Generating knowledge and sharing it with society

July 12, 2018: This has been the motivation with which Jonathan Schiefer has conducted his research. Now the Bernstein Center Freiburg would like to congratulate him on his successful dissertation on "Inference of multi-scale connectivity in the brain".

Read More…

Reciprocity of social influence: Who do we take advice from and why?

Reciprocity of social influence: Who do we take advice from and why?

June 28, 2018: New insights in social decision making: our influence on others highly affects how much influence we take from them

Read More…

Informative Video about the Bernstein Center Freiburg

Informative Video about the Bernstein Center Freiburg

June 20, 2018: Are you interested in briefly seeing what our work is about? Then, watch our video on our Youtube Channel. We wish to thank the Bernstein Network Computational Neuroscience, who instigated this video production and made it financially possible.

Read More…

Personal tools