The Bernstein Center Freiburg

Informal Seminar
Márton A. Hajnal

MTA Wigner Research Centre for Physics (KFKI)
and Eötvös Loránd University
Budapest, Hungary

ACh and DA neuromodulation
in striatal projection neurons

During synchronous cortical and thalamic inputs to striatal projection neurons, basal ganglia interneuron, feedforward, and feedback activity is also suspected to be coordinated. These inputs computationally converge onto the projection neurons, exciting meaningful basal ganglia response, that links action to associations and environment. It can manifest as a prediction of outcome of choices or actions to aid a decision, or starting and stopping a movement program, or learning to associate an action with internal and outside conditions, etc. Such usual responses can be augmented by a change in cholinerg firing pattern during salient environmental or internal conditions, as well as change in dopaminerg firing pattern during predicted or actual rewards associated with the action. Modelled by varying timecourses of ACh and DA concentration changes on a detailed biophysical model, this study examines how saliency and rewards influence the response patterns of striatonigral and striatopallidal projection neurons. Effects found to be important are input selectivity, noise filtering, contrast enhancement, long term learning-forgetting patterns and stimulus timecourse dependent interplay amongst cholinerg, dopaminerg, striatonigral and striatopallidal cells.

Monday, October 27, 2014

17:15 h
Seminar Room "Casino"
BCF basement
Hansastr. 9a
The talk is open to the public. Guests are cordially invited!