The Bernstein Center Freiburg

Informal Seminar
Marco Brigham

Centre National de la Recherche Scientifique
Unit of Neuroscience Information and Complexity
Gif-sur-Yvette, France

Modelling membrane potential fluctuations
with shot noise

Shot noise is quite often used to model different aspects of neural activity, in particular when system response to Poisson inputs can be characterized by the sum of individual responses.

Applications of shot noise have quite often been confined to:

1) Stationary regime
2) Markovian post-synaptic responses
3) Homogeneous Poisson inputs

In this work we use shot-noise formalism to analyse sub-threshold membrane potential activity of neurons beyond stationarity, for any type of bounded post-synaptic response and inhomogeneous Poisson pre-synaptic spikes.

Using this formalism we have obtained exact expressions for higher order moments and densities of post-synaptic and sub-threshold membrane potential responses to network activity, even in non-stationary conditions.
In conclusion, this work opens the route towards methods to estimate synaptic conductances from Vm fluctuations, as well as an analytic approach to the transfer function of neurons.

Supported by FACETS-ITN, work done in supervision by A. Destexhe
Wednesday, July 31, 2013

15:00 h
BCF Library
First Floor
Hansastr. 9a
The talk is open to the public. Guests are cordially invited!