The Bernstein Center for Computational Neuroscience Freiburg


Announcement for the next
BCCN Seminar
Dr. Stefan Leutgeb
Centre for the Biology of Memory
Trondheim
Norway
HOW CAN INTRAHIPPOCAMPAL NETWORK DYNAMICS CONTRIBUTE TO THE ENCODING AND RETRIEVAL OF MEMORIES?
Thursday, December 07, 2006
17:15h
Lecture Hall (ground floor)
BCCN building
Hansastraße 9A
79104 Freiburg
Abstract:
Autobiographical memories are the very foundation for a personís self and are central to meaningful lives and social interactions. Although we now have a good understanding about memory tasks that require the medial temporal lobes, we know less well how cell populations in the hippocampus and the parahippocampal cortices communicate to support memory encoding and retrieval. Studying neuronal population dynamics with large-scale single-unit recordings has emerged as a powerful tool to advance our understanding of memory processing in these regions. Recent data suggest that spatial processing, which has previously been attributed to hippocampus, may already take place upstream, in the entorhinal cortex. Hippocampal cells and circuits, in particular those in the dentate gyrus and CA3, may thus support functions specific to memory. They can add new information to already learned knowledge while, at the same time, keeping related pieces of information separate by decorrelating input patterns. For example, the different network architectures of the dentate gyrus and CA3 area allow for two separate mechanisms for neuronal pattern separation. Identifying the contribution of hippocampal neural network dynamics to memory storage will not only advance our understanding of these processes in the intact brain but also have important implications for treating of memory-related disorders.
The talk is open to the public. Guests are cordially invited!
www.bccn.uni-freiburg.de