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C5: Multicontact stimulation techniques for interventions in human focal epilepsy

Andreas Schulze-BonhageI, Thomas StieglitzX, Rudi MattmüllerZ

 
I = Epilepsy Centre, University Medical Center
X = Biomedical Microtechnology
Z = Inomed

 

Scientific background

Epilepsy is one of the most common diseases of the human brain with more than 600.000 patients of all ages affected in Germany alone. Present-day treatment by systemically applied pharmacotherapy does not control seizures in 30-40% of patients. Microsurgical resections may be performed in part of these. Brain stimulation is a new approach, so far clinically limited to open-loop stimulation of the vagus nerve, with moderate efficacy. Local stimulation techniques may offer new chances to suppress epileptic activity at the site of their origin. So far, optimal stimulation paradigms and stimulus sites have not been investigated in a systematic way, and only open-loop stimulation is performed.
Our group has extensive experience with the use of intracranial depth and subdural EEG recordings in humans and animals. In addition, there is expertise in the development of electrodes and with recording and stimulation technology. Furthermore, the Freiburg Epilepsy Center takes part in an ongoing international study of open-loop hippocampal stimulation for the treatment of mesiotemporal epilepsy.


Objectives

This project aims at the development and testing of multichannel open- and closed-loop stimulations strategies for the treatment of epileptogenic regions unamenable to epilepsy surgery. We will develop clinical multichannel epicortical intervention strategies and hardware components for improved epileptic focus stimulation in both, open- and closed-loop settings.

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