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Jens Timmer

Faculty


Principal Investigator in

 

Research Topics

  • Data analysis and modeling of dynamic processes in the life sciences

 

Techniques

  • Spectral analysis
  • Cross spectra
  • Higher order spectra
  • Synchronization analysis
  • Hidden Markov models
  • Parameter estimation in dynamical systems
  • Nonlinear dynamics

 

CV

Academic Background

  • 1999: "Habilitation", Department of Physics, University of Freiburg
  • 1994: PhD in Physics, Thesis: Preprocessing, modelling and classification of time series1990 - 1994: PhD studies, Department of Physics, University of Freiburg1990: "Diplom" in Physics
  • 1983 - 1990: Studies in Physics, University Utrecht and University Freiburg

 

Research Positions

  • 2000 - present: "Hochschuldozent", equivalent to Associate Professor, Department of Physics, University of Freiburg
  • 1998 - 2000: "Hochschulassistent", equivalent to Assistant Professor, Department of Physics, University of Freiburg
  • 1994 - present: Group leader at the Centre for Data Analyses and Modelling, University of Freiburg

 

Scientific Honors, Editorial Boards, Other Scientific Activities

  • 2003 - present: Member Federal Steering Comitee Systems Biology of Microorganims
  • 2003 - present: Speaker of the Federal competence network Systems Biology of the Hepatocyte
  • 2003 - present: Member Board of Founding Directors for Centre for Systems Biology, University of Freiburg
  • 1992 - present: Referee for 27 journals from mathematics, physics, biology and medicine
  • 1994:  Research award for Ph.D. thesis from the "Wissenschaftliche Gesellschaft", Freiburg

 

Publications

  • D. Onichtchouk, F. Geier, B. Polok, D. Messerschmidt, R. Mössner, B. Wendik, S. Song, V. Taylor, J. Timmer, W. Driever.
    Zebrafish Oct4/Pou5f1-dependent transcriptional networks in temporal control of early development.
    Molecular Systems Biology , 2010
  • J. Nawrath, M.C. Romano, M. Thiel, I.Z. Kiss, M. Wickramasinghe, J. Timmer, J. Kurths, B. Schelter.
    Distinguishing direct and indirect interactions in oscillatory networks with multiple time scales. Phys. Rev. Lett. , 2010,
  • B. Schelter, J. Timmer, H. Feldwisch, J. Gotman, A. Schulze-Bonhage.
    A common strategy and database to compare the performance of seizure prediction algorithms. Epilepsy & Behavior , 2010,
  • D. Saur, W. Mader, S. Schnell, P. Kellmeyer, D. Kratochvil, H. Küpper, D. Kümmerer, V. Glauche, R. Lange, D. Feess, B. Schelter, J. Timmer, C. Weiller.
    Brain Networks for phonological and semantic processing in auditory language comprehension. Neuroimage , 2010,
  • H. Feldwisch, B.Schelter, M. Jachan, J. Nawrath, J. Timmer J., A. Schulze-Bonhage.
    Joining the benefits: Combining epileptic seizures prediction methods. Epilepsia , 2010,
  • M. Reinhard, F. Neunhoeffer, T.A. Gerds, W.-D. Niesen, K.-J. Buttler, J. Timmer, B. Schmidt, M. Czosnyka, C. Weiller, A. Hetzel.
  • Secondary decline of cerebral autoregulation associates with worse outcome after intracerebral hemorrhage. Intensive Care Medicine , 2010,
  • [197] M. Schilling, T. Maiwald, S. Hengl, D. Winter, C. Kreutz, W. Kolch, W.D. Lehmann, J. Timmer, U. Klingmüller.
    Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. Molecular Systems Biology 5, 2009, 334
    Supplementary Information
  • [196] L. Sommerlade, M. Eichler, M. Jachan, K. Henschel, J. Timmer, B. Schelter.
    Estimating causal dependencies in networks of nonlinear stochastic dynamical systems. Phys. Rev. E 80, 2009, 051128
  • [195] L. Sommerlade, K. Henschel, J. Wohlmuth, M. Jachan, F. Amtage, B. Hellwig, C.H. Lücking, J. Timmer, B. Schelter.
    Time-variant estimation of directed influence during Parkinsonian tremor. J. Physiol.103, 2009, 348-352
  • [194] J. Rausenberger, C. Fleck, J. Timmer, M. Kollmann.
    Signature of gene expression noise in cellular systems. Progress Biophysics Molecular Biology 100, 2009, 57-66
  • [193] V. Petrov, J. Timmer.
    One-dimensional model of somitic cells polarization in a bistability window of embryonic mesoderm. Mechanics in Medicine and Biology 9, 2009, 259-272
  • [192] F. Amtage, K. Henschel, B. Schelter, J. Vesper, J. Timmer, C.H. Lücking, B. Hellwig.
    High functional connectivity of tremor related subthalamic neurons in Parkinson's disease. Clinical Neurophys. 120, 2009, 1755-1761
  • [191] N. Philippi, D. Walter, R. Schlatter, K.S. Ferreira, M. Ederer, O. Sawodny, J. Timmer, C. Borner, T. Dandekar.
    Modeling system states in liver cells: Survival, apoptosis and their modifications in response to viral infection. BMC Systems Biology 3, 2009, 97
  • [190] M. Jachan, K. Henschel, J. Nawrath, A. Schad, J. Timmer, B. Schelter.
    Inferring direct directed information flow from multivariate non-linear time series. Phys. Rev. E 80, 2009, 011138
  • [189] A. Raue, C. Kreutz, T. Maiwald, J. Bachmann, M. Schilling, U. Klingmüller, J. Timmer.
    Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood. Bioinformatics 25, 2009, 1923-1929
    Supplementary Information
  • [188] M. Jachan, M. Reinhard, L. Spindeler, A. Hetzel, B. Schelter, J. Timmer.
    Parametric versus nonparametric transfer function estimation of cerebral autoregulation from spontaneous blood-pressure oscillations. Cardiovascular Engineering 9, 2009, 72-82
  • [187] M. Buchner, S. Fuchs, G. Prinz, D. Pfeifer, K. Bartholome, M. Burger, N. Chevalier, L. Vallat, J. Timmer, J.G. Gribben, H. Jumaa, H. Veelken, C. Dierks, K. Zirlik.
    Spleen Tyrosine Kinase (SYK) is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia. Cancer Research 69, 2009, 5424-5432
  • [186] Bartholome K., Kreutz C., Timmer J.
    Estimating of gene induction enables a relevance-based ranking of genes sets. J. Comp. Biol. 16, 2009, 959-967
  • [185] B. Rumberger, C. Kreutz, C. Nickel, M. Klein, S. Lagoutte, S. Teschner, J. Timmer, G. Walz.
    Combination of immunosuppressive drugs leaves specific ''fingerprint'' on gene expression in vitro. Immunopharmacology Immunotoxicology 31, 2009, 283-292
  • [184] K. Wester, S. Digiuni, F. Geier, J. Timmer, C. Fleck, M. Hülskamp.
    Functional diversity of R3 single-repeat genes in trichome development. Development 136, 2009, 1487-1496
  • [183] N. Borisov, E. Aksamitiene, A. Kiyatkin, S. Legewie, J. Berkhout, T. Maiwald, N.P. Kaimachnikov, J. Timmer, J.B. Hoek, B.N. Kholodenko.
    Systems-level interactions between insulin-EGF networks amplify mitogenic signaling. Mol. Sys. Bio. 5, 2009, 256
  • [182] T. Wiech, E. Nikolopoulos, R. Weis, R. Langer, K. Bartholome, J. Timmer, A. Walch, H. Höfler, M. Werner.
    Genome-wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arrays. Laboratory Investigation 89, 2009, 385-397
  • [181] Mammen E., Nandi S., Maiwald T., Timmer J.
    Effect of jump discontinuity for phase-randomized surrogate data testing. Int. J. Bif. Chaos 19, 2009, 403-408
  • [180] B. Schelter, J. Timmer, M. Eichler.
    Assessing the strength of directed influences among neural signals using renormalized partial directed coherence. J. Neuroscience Methods 179, 2009, 121-130
  • [179] S. Lassmann, C. Kreutz, A. Schoepflin, U. Hopt, J. Timmer, M. Werner.
    A novel approach for reliable microarray analysis of microdissected tumour cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens. J. Molecular Medicine 87, 2009, 211-224
  • [178] Hellwig B., Mund P., Schelter B. Guschlbauer B., Timmer J., Lücking C.H.
    A longitudinal study of tremor frequencies in Parkinson's disease and essential tremor. Clinical Neurophysiology 120, 2009, 431-435
  • [177] M. Gerstung, J. Timmer, C. Fleck.
    Noisy signalling through promoter logic gates. Phys. Rev. E 79, 2009, 11923
  • [176] Kreutz C., Timmer J.
    Systems biology: experimental design. FEBS Journal 276, 2009, 923-942
  • [175] M. Joschko, R. Gebbers, D. Barkusky, J. Rogasik, W. Höhn, W. Hierold, C.A. Fox, J. Timmer.
    Location-dependency of earthworm response to reduced tillage on sandy soil. Soil & Tillage Research 102, 2009, 55-66
  • [174] W. Mader, D. Feess, R. Lange, D. Saur, V. Glauche, C. Weiller, J. Timmer, B. Schelter.
    On the detection of direct directed information flow in fMRI. IEEE J. Sel. Topics in Signal Processing 2, 2008, 965-974
  • [173] K. Henschel, B. Hellwig, F. Amtage, M. Jachan, C.H. Lücking, J. Timmer, B. Schelter.
    Multivariate Analyis of dynamical processes: Point processes and time series. Europ. Phys. J. 165, 2008, 25-34
  • [172] F. Geier, J.U. Lohmann, M. Gerstung, A.T. Maier, J. Timmer, C. Fleck.
    A quantitative and dynamic model for plant stem cell regulation. PLoS One 3, 2008, e3553
  • [171] M. Reinhard, T.A. Gerds, D. Grabiak, P. Zimmermann, M. Roth, B. Guschlbauer, J. Timmer, M. Czosnyka, C. Weiller, A. Hetzel.
    Cerebral dysautoregulation and the risk of ischemic events in occlusive carotid artery disease. J. Neurology 255, 2008, 195-199
  • [170] M. Reinhard, Z. Waldkircher, B. Guschlbaur, J. Timmer, C. Weiller, A. Hetzel.
    Cerebellar autoregulation dynamics in humans. J. Cerebral Blood Flow Metabolism 28, 2008, 1605-1612
  • [169] S. Digiuni, S. Schellmann, F. Geier, B. Greese, M. Pesch. K. Wester, B. Dartan, V. Mach, B. P. Srinivas, J. Timmer, C. Fleck, M. Hülskamp.
    A competitive complex formation mechanism underlies trichome patterning on Arabidopsis leaves. Mol. Sys. Bio. 4, 2008, 217
    Supplementary Information
  • [168] T. Maiwald, J. Timmer
    Dynamical modeling and multi-experiment fitting with PottersWheel. Bioinformatics 24, 2008, 2037-2043
    Supplementary Information
  • [167] F. Amtage, K. Henschel, B. Schelter, J. Vesper, J. Timmer, C. Weiller, C.H. Lücking, B. Hellwig.
    Tremor-correlated neuronal activity in the subthalamic nucleus of Parkinsonian patients. Neuroscience Lett. 442, 2008, 195-199
  • [166] M. Joschko, J. Oehley, R. Gebbers, M. Wiemer, J. Timmer, C.A. Fox.
    A spatial approach to soil-ecological experimentation at landscape scale. J. Plant Nutr. Soil Science 171, 2008, 339-343
  • [165] M. Reinhard, C. Wihler, M. Roth, A. Harloff, W.-D. Niesen, J. Timmer, C. Weiller, A. Hetzel.
    Cerebral autoregulation dynamics in acute ischemic stroke after rtPA thrombolysis. Cerebrovascular Diseases 26, 2008, 147-155
  • [164] Bartholome K, Timmer J.
    Regulatory principles and systems analysis of bacterial chemotaxis. AT Automatisierungstechnik 56, 2008, 241-249
  • [163] D. Bouyer, F. Geier, F. Kragler, A. Schnittger, M. Pesch, K. Wester, R. Balkunde, J. Timmer, C. Fleck, M. Hülskamp.
    Two-dimensional patterning by a trapping/depletion mechanism: The role of TTG1 and GL3 in Arabidopsis trichome formation. PloS Biology 6, 2008, e141
  • [162] J. Vera , J. Bachmann, A.C. Pfeifer, V. Becker, J.A. Hormiga, N.V. Torres Darias, J. Timmer, U. Klingmüller, O. Wolkenhauer.
    A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway. BMC Systems Biology 2, 2008, 38
    Supplementary Information
  • [161] E. Balsa-Canto, M. Peifer, J.R. Banga, J. Timmer, C. Fleck.
    Hybrid optimization method with general switching strategy for parameter estimation. BMC Systems Biology 2, 2008, 26
  • [160] A. Schad, K. Schindler, M. Winterhalder, B. Schelter, T. Maiwald, A. Brandt, J. Timmer, A. Schulze-Bonhage.
    Application of a multivariate seizure detection and prediction method to non-invasive and intracranial long-term EEG recordings. Clinical Neurophysiology 119, 2008, 197-211
  • [159] T. Maiwald, C. Kreutz, A. Pfeifer, S. Bohl, U. Klingmüller, J. Timmer.
    Dynamic pathway modeling - Feasibility analysis and optimal experimental design. Annals New York Acad. Sci. 1115, 2007, 212-220
  • [158] Winterhalder M., Schelter B., Timmer J.
    Detecting coupling directions in multivariate oscillatory systems. Int. J. Bif. Chaos 17, 2007, 3735-3739
  • [157] Schelter B., Winterhalder M., Kurths J., Timmer J.
    Phase synchronization and coherence analysis: sensitivity and specificity. Int. J. Bif. Chaos 17, 2007, 3551-3556
  • [156] E. Anastasiou, S. Kenz, M. Gerstung, D. MacLean, J. Timmer, C. Fleck, M. Lenhard.
    Control of plant organ size by KLUH/CYP78A5-dependent intracellular signalling. Developmental Cell 13 , 2007, 843-856
  • [155] C. Kreutz, M.M. Bartholome Rodriguez, T. Maiwald, M. Seidl, H.E. Blum, L. Mohr, J. Timmer.
    An error model for protein quantification. Bioinformatics 23, 2007, 2747-2753
    Supplementary Information
  • [154] Hengl S., Kreutz C., Timmer J. Maiwald T.
    Data-dased identifiability analysis of nonlinear dynamical models. Bioinformatics 23, 2007, 2612-2618
    Supplementary Information
  • [153] Rumberger B., Vonend O., Kreutz C., Wilpert J., Donauer J., Amann K., Rohrbach R., Timmer J., Walz G., Gerke P.
    cDNA mircoarray analysis of adaptive changes after renal ablation in a sclerosis-resistant mouse strain. Kidney Blood Pressure Res. 30, 2007, 377-378
  • [152] Bartholome K., Rius M., Letschert K., Keller D. Timmer J., Keppler D.
    Data-based mathematical modeling of vectorial transport across double-transfected polarized cells. Drug Metabolism and Disposition 35, 2007, 1476-1481
    Supplementary Information
  • [151] Reinhard M., Wehrle-Wieland E., Roth M., Niesen W.D., Timmer, J. Weiller C., Hetzel A.
    Preserved dynamic cerebral autoregulation in the middle cerebral artery among persons with migraine. Exp. Brain Res. 180, 2007, 517-523
  • [150] Schelter B., Peifer M., Winterhalder M., Timmer J.
    Testing for phase synchronization. Phys. Lett. A 366, 2007, 382-390
  • [149] Peifer M., Timmer J.
    Parameter estimation in ordinary differential equations for biochemical processes using the method of multiple shooting. IET Systems Biology 1, 2007, 78-88.
  • [148] Lindenmeyer M.T., Kern C., Sparna T. Donauer J., Wilpert J., Schwager J., Porath D. Kreutz C., Timmer J., Merfort I.
    Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells. Life Sciences 80, 2007, 1608-1618
  • [147] Geier F., Timmer J., Fleck C.
    Reconstructing gene-regulatory networks from time series, knock-out data, and prior knowledge. BMC Systems Biology 1, 2007, 11
  • [146] Schelter B., Winterhalder M., Feldwisch H., Wohlmuth J., Nawrath J., Brandt A., Schulze-Bonhage A., Timmer J.
    Seizure prediction: The impact of long prediction horizons. Epilepsy Research 73, 2007, 213-217
  • [145] Smirnov D., Schelter B., Winterhalder M., Timmer J.
    Revealing direction of coupling between neuronal oscillators from time series: Phase dynamics modeling versus partial directed coherence. Chaos 17, 2007, 013111
  • [144] Pfeifer D., Pantic M., Skatulla I., Rawluk J., Kreutz C., Martens U., Fisch P., Timmer J., Veelken H.
    Genome-wide analysis of DNA copy number changes in CLL using high-density SNP arrays. Blood 109, 2007, 1202-1210
  • [143] Sick S., Reinker S., Timmer J., Schlake T.
    WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism. Science 314, 2006, 1447-1450
    Supplementary Information
    Science Perspective
    Preview in Cell
  • [142] Schelter B., Winterhalder M., Maiwald T., Brandt A., Schad A., Timmer J., Schulze-Bonhage A.
    Do false predictions of seizure depend on the state of vigilance? A report from two seizure prediction methods and proposed remedies. Epilepsia 47, 2006, 2058-2070
  • [141] Klingmüller U., Bauer A., Bohl S., Nickel P., Breitkopf K., Dooley S., Zellmer S., Kern C., Merfort I, Sparna T., Donauer J., Walz G., Geyer M., Kreutz C., Hermes M., Götschel F., Hecht A., Walter D., Egger L., Neubert K., Borner C., Brulport M., Schormann W., Sauer C., Baumann F., Preiss R., MacNelly S., Godoy P., Wiercinska E., Ciuclan L., Edelmann J., Kleemann W.J., Zeilinger K., Heinrich M., Zanger U.M., Reuss M., Bader A., Gebhardt R., Maiwald T., Timmer J., von Weizsäcker F., Hengstler J.G.
    Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. IEE Proc. Systems Biology 153, 2006, 433-447
  • [140] Winterhalder M., Schelter B., Hesse W., Schwab K., Leistritz L., Timmer J. and Witte H.
    Detection of directed information flow in multidimensional biosignals. Biomed. Tech. 51, 2006, 281-287
  • [139] Warnke P.C., Kopitzki K., Timmer J., Ostertag C.B.
    Capillary physiology of human medulloblastoma - Impact on chemotherapy. Cancer 107, 2006, 2223-2227
  • [138] Reinhard M., Wehrle-Wieland E., Grabiak D., Roth M., Guschlbauer B., Timmer J., Weiller C., Hetzel A.
    Oscillatory cerebral hemodynamics - the macro- vs. microvascular level. J. Neurol. Sci. 250, 2006, 103-109
  • [137] Winterhalder M., Schelter B., Schulze-Bonhage A., Timmer J.
    Comment on: "Performance of a seizure warning algorithm based on the dynamics of intracranial EEG". Epilepsy Res. 72, 2006, 80-81
  • [136] Winterhalder M., Schelter B., Maiwald T., Brandt A., Schad A., Schulze-Bonhage A., Timmer J.
    Spatio-temporal patient-individual assessment of synchronization changes for epileptic seizure prediction. Clin. Neurophys. 117, 2006, 2399-2413
  • [135] Schieren G., Rumberger B., Klein M., Kreutz C., Wilpert J., Geyer M., Faller D., Timmer J., Quack I., Rump L.C., Walz G., Donauer J.
    Gene profiling of polycystic kidneys. Nephrol. Dial. Transplant. 21, 2006, 1816-1824
  • [134] Reinker S., Altman R.M., Timmer J.
    Parameter estimation in stochastic biochemical reactions. IEE Trans. Syst. Biol. 153, 2006, 168-178
  • [133] Winterhalder M., Schelter B., Kurths J., Schulze-Bonhage A., Timmer J.
    Sensitivity and specificity of coherence and phase synchronization analysis. Phys. Lett. A 356, 2006, 26-34
  • [132] Petrov V., Peifer M., Timmer J.
    Bistability and self-oscillations in cell cycle control. Int. J. Bif. Chaos 16, 2006, 1057-1066
  • [131] Fang X., Zeisel M.B., Wilpert J., Gissler B., Thimme R., Kreutz C., Maiwald T., Timmer J., Kern W.V., Donauer J., Geyer M., Walz G., Delpa E., von Weizsäcker F., Blum H.E., Baumert T.F.
    Host cell responses induced by Hepatitis C virus binding. Hepatology 43, 2006, 1326-1336
  • [130] Schelter B., Winterhalder M. Kurths J., Dahlhaus R., Timmer J.
    Partial-phase synchronization for multivariate synchronizing systems. Phys. Rev. Lett. 96, 2006, 208103
  • [129] The Y.-K., Fernandez J., Popa M.O., Alekov A.K., Timmer J., Lerche H.
    Modeling of single non-inactivating Na channels: evidence for two open and several fast inactivated states. Biophys. J. 90, 2006, 3511-3522
  • [128] Schelter B., Winterhalder M., Eichler M., Peifer M., Hellwig B., Guschlbauer B., Lücking C.H., Dahlhaus R., Timmer J.
    Testing for directed influences among neural signals using partial directed coherence. Journal of Neuroscience Methods 152, 2006, 210-219
  • [127] The Y.-K., Timmer J.
    Analysis of single ion channel data incorporating time interval omission and sampling. J. Roy. Soc. Interface 3, 2006, 87-97
  • [126] Schelter, B., Winterhalder M., Maiwald T., Brandt A., Schad A., Schulze-Bonhage A., Timmer J.
    Testing statistical significance of multivariate time series methods for epileptic seizure prediction. Chaos 16, 2006, 013108
  • [125] Joschko M., Fox,C., Lentzsch P., Kiesel J., Hierold W., Krück S., Timmer J.
    Spatial analysis of earthworm biodiversity at the regional scale. Agriculture, Ecosystems & Environment 112, 2006, 367-380
  • [124] Schelter B., Winterhalder M., Hellwig B., Guschlbauer B., Lücking C.H., Timmer J.
    Direct or Indirect ? Graphical models for neural oscillators. J. Physiol. 99, 2006, 37-46
  • [123] Kollmann M., Bartholome K., Lovdok L., Timmer J., Sourjik V.
    Design principles of a bacterial signalling network. Nature 438, 2005, 504-507
    Supplementary Information
  • [122] Schilling M,. Maiwald T., Bohl S., Kollmann M., Kreutz C., Timmer J., Klingmüller U.
    Quantitative data generation for systems biology - the impact of randomisation, calibrators and normalisers. IEE Proc. Systems Biology 152, 2005, 193-200
  • [121] Schilling M., Maiwald T., Bohl S., Kollmann M., Kreutz C., Timmer J., Klingmüller U.
    Computational processing and error reduction strategies for standardized quantitative data in biological networks. FEBS Journal 272, 2005, 6400-6411
    Supplementary Information
  • [120] Winterhalder M., Schelter B., Hesse W., Schwab K., Leistritz L., Klan D., Bauer R., Timmer J., Witte H.
    Comparison of linear signal processing techniques to infer directed interactions in multivariate neural systems. Signal Processing 85, 2005, 2137-2160
  • [119] Peifer M., Schelter B., Winterhalder M., Timmer J.
    Mixing properties of the Rossler system and consequences for coherence and synchronization analysis. Phys. Rev. E 72, 2005, 026213
  • [118] Reinhard M., Roth M., Guschlbauer B., Harloff A., Timmer J., Czosnyka M., Hetzel A.
    Dynamic cerebral autoregulation in acute ischemic stroke assessed from spontaneous blood pressure fluctuations. Stroke 36, 2005, 1684-1689
  • [117] Peifer M., Schelter B., Guschlbauer B., Hellwig B., Luecking C.H., Timmer J.
    On studentising and blocklength selection for the bootstrap on time series. Biometrical Journal 47, 2005, 346-357
  • [116] Petrov V., Peifer M., Timmer J.
    Structural stability analysis of a cell cycle control model. Comptes rendus de l'Acad. Bulg. Sci. 58, 2005, 19-24
  • [115] The Y.-K., Fernandez J., Popa O., Lerche H., Timmer J.
    Estimating rate constants from single ion channel currents when the initial distribution is known. Eur. Biophys. J. 34 , 2005, 306-313
  • [114] Goerttler P.S., Kreutz C., Donauer J., Faller D., Maiwald T., Klein M., März E., Rumberger B. Sparna T., Schmitt-Gräff A., Wilpert J., Timmer J., Walz G., Pahl H.
    Gene Expression Profiling in Polycythemia vera: Overexpression of transcription factor NF-E2. British Journal of Haematology 129, 2005, 138-150
  • [113] Warnke P.C., Timmer J., Ostertag C.B., Kopitzki K.
    Capillary physiology and drug delivery in central nervous system lymphomas. Annals Neurology 57, 2005, 136-139
  • [112] von Gruenberg H.H., Peifer M., Timmer J., Kollmann M.
    Variations in substitution rate in human and mouse genomes. Phys. Rev. Lett. 93, 2004, 208102
  • [111] Rossberg A., Bartholome K., Voss H.U., Timmer J.
    Phase synchronization from noisy univariate signals. Phys. Rev. Lett. 93, 2004, 154103
  • [110] Petrov V., Timmer J.
    Bifurcation Analysis of a Cell Mitosis Control Model. J. Theor. Appl. Mech. 34, 2004, 87-100
  • [109] Petrov V., Nikolova E., Timmer J.
    Dynamical Analysis of Cell Function Models. A Review. J. Theor. Appl. Mech. 34, 2004, 55-78
  • [108] Petrov V., Peifer M., Timmer J.
    Constructing Dynamical Model of Cell Cycle Control. Comptes Rendus de l'Acad. Bulg. Sci. 57, 2004, 15-22
  • [107] Maraun D., Rust H., and Timmer, J.
    Tempting long-memory - on the interpretation of DFA results. Nonlinear Processes in Geophysics 11, 2004, 495-503
  • [106] Steltner H., Vogel A., Sprung E., Timmer J., Guttmann J., Sorichter S.
    Incomplete forced expiration - estimating vital capacity by a mathematical method. Respiration 71, 2004, 353-359
  • [105] Raethjen J., Lauk M., Pawlas F., Koster B., Fietzek U., Friege L., Timmer J., Lucking C.H., Deuschl G.
    Tremor analysis in two normal cohorts. Clin. Neurophys. 115, 2004, 2151-2156
  • [104] Müller T.G., Faller D., Timmer J., Swameye I., Sandra O., Klingmüller U.
    Tests for cycling in a signalling pathway. J. Roy. Stat. Soc. C: Applied Stat. 53, 2004, 557 - 568
  • [103] Thiel M., Romano, M.C., Schwarz U., Kurths J., Timmer J.
    Surrogate based hypothesis test without surrogates. Int. J. Bif. Chaos 14, 2004, 2107-2114
  • [102] Maraun D., Horbelt W., Rust H., Timmer J., Happersberger H.P., Drepper F.
    Identificaton of rate constants and non-observable absorption spectra in nonlinear biochemical reaction dynamics. Int. J. Bif. Chaos 14, 2004, 2081-2092
  • [101] Müller T.G., Timmer J.
    Parameter identification techniques for partial differential equations. Int. J. Bif. Chaos 14, 2004, 2053-2060
  • [100] Timmer J., Müller T.G., Swameye I., Sandra O., Klingmüller U.
    Modelling the nonlinear dynamics of cellular signal transduction. Int. J. Bif. Chaos 14, 2004, 2069-2079
  • [99] Voss H.U., Timmer J., Kurths J.
    Nonlinear dynamical system identification from uncertain and incomplete measurements. Int. J. Bif. Chaos 14, 2004, 1905-1933
  • [98] Maiwald T., Winterhalder M., Aschenbrenner-Scheibe R., Voss H.U., Schulze-Bonhage A., Timmer J.
    Comparison of three nonlinear seizure prediction methods by means of the seizure prediction characteristic. Physica D 194, 2004, 357-368
  • [97] Reinhard M., Roth M., Muller T, Guschlbauer B., Czosnyka M., Timmer J, Hetzel A.
    Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulation. Stroke 35, 2004, 1381-1387
  • [96] Raethjen J., Lindemann M., Morsnowski A., Dümpelmann M., Wenzelburger R., Stolze H., Fietzek U., Pfister G., Elgar C.E., Timmer J., Deuschl G.
    Is the rhythm of physiological tremor involved in cortico-cortical interactions ? Movement Disorders 19, 2004, 458-465
  • [95] Faller D., Reinheckel T., Wenzler D., Hagemann S., Xiao K., Honerkamp J., Peters Ch., Dandekar T., Timmer J.
    An open source protein gel documentation system for proteome analyses, J. Chem. Inf. Comp. Sci. 44, 2004, 168-169
  • [94] Bertram C.D., Timmer J., Muller T.G., Maiwald T., Winterhalder M., Voss H.U.
    Aperiodic flow-induced oscillations of collapsible tubes: a critical reappraisal. Medical Engineering & Physics 26, 2004, 201-214
  • [93] Rossberg A.G., Bartholome K., Timmer J.
    Data driven optimal filtering for phase and frequency of noisy oscillations application to vortex flowmetering. Phys. Rev. E 69, 2004, 016216
  • [92] Rossberg A.G., Riegler P., Buhl F., Herwig J., Timmer J.
    Detection of improper installation from the sensor signal of vortex flowmeters. Flow Measurement and Instrumentation 15, 2004, 29-35
  • [91] Faller D., Klingmüller U., Timmer J.
    Simulation methods for optimal experimental design in systems biology. Simulation: Trans. Soc. Modeling Computer Simulation 79, 2003, 717-725
  • [90] Müller T., Lauk M., Reinhardt M., Hetzel A., Lücking C.H., Timmer J.
    Estimation of time-delays in biological systems, Annals Biomed. Eng. 31, 2003, 1423-1439
  • [89] Reinhard M., Müller T., Roth M., Guschlbauer B., Timmer J., Hetzel A.
    Bilateral severe carotid artery stenosis or occlusion - cerebral autoregulation dynamics and collateral flow patterns Acta Neurochirurgica 145, 2003, 1053-1060
  • [88] Peifer M., Timmer J., Voss H.U.
    Non-parametric identification of non-linear oscillating systems. J. Sound Vib. 267, 2003, 1157-1167
  • [87] Aschenbrenner-Schiebe R., Maiwald T., Winterhalder M., Voss H.U., Timmer J., Schulze-Bonhage A.
    How well can epileptic seizures be predicted? An evaluation of a nonlinear method. Brain 216, 2003, 2616-2626
  • [86] Donauer J., Rumberger B.G., Klein M., Faller D., Wilpert J., Sparna T., Schieren G., Rohrbach R., Dern P., Timmer J., Pisarski P., Kirste G., Walz G.
    Expression profiling on chronically rejected transplant kidneys. Transplantation 76, 2003, 539-547.
  • [85] Reinhard, M., Roth, M., Müller, T., Czosnyka, M., Timmer, J., Hetzel, A.
    Cerebral autoregulation in carotid artery occlusive disease assessed from spontaneous blood pressure fluctuations by the correlation coefficient index. Stroke 34, 2003, 2138-2244
  • [84] Kappler B., Tuchbreiter A., Faller D., Liebetraut P., Horbelt W., Timmer J., Honerkamp J., Mülhaupt R.
    Real-time monitoring of ethene/1-hexene copolymerizations: Determination of catalyst activity, copolymer composition and copolymerization parameters. Polymer 44, 2003, 6179-6186
  • [83] Faller D., Voss H.U., Timmer J., Hobohm U.
    Normalization of DNA-mircoarray data by nonlinear correlation maximization. J. Comp. Biol. 10, 2003, 751-761
  • [82] Reinhard M., Roth M., Müller T., Guschlbauer B., Timmer J., Hetzel A.
    Dynamic cerebral autoregulation and collateral flow patterns in patients with severe carotid stenosis or occlusion. Ultrasound Med. Biol. 29, 2003, 1105-1113
  • [81] Hellwig B., Schelter B., Guschlbauer B., Timmer J., Lücking C.H.
    Dynamic synchronisation of central oscillators in essential tremor. Clinical Neurophysiology 114, 2003, 1462-1467
  • [80] Voss H.U., Rust H., Horbelt W., Timmer J.
    A combined approach for the identification of continuous nonlinear systems. Int. J. Adaptive Control 17, 2003, 335-352
  • [79] Winterhalder M., Maiwald T., Aschenbrenner-Schiebe R., Voss H.U., Timmer J., Schulze-Bonhage A.
    The seizure prediction characteristic: A general framework to assess and compare seizure prediction methods. Epilepsy and Behavior 4, 2003, 318 - 325
  • [78] Horbelt W., Timmer J.
    Asymptotic scaling laws for precision of parameter estimates in dynamical systems. Phys. Lett. A 310, 2003, 269-280
  • [77] Müller T., Reinhard M., Oehm E., Hetzel A., Timmer J.
    Detection of very low frequency oscillations of cerebral hemodyamics is influenced by data detrending. Med. & Biol. Eng. & Comp. 41, 2003, 69-74
  • [76] Swameye I., Müller T.G., Timmer J., Sandra O., Klingmüller U.
    Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by data-based modeling. Proc. Natl. Acad. Sci. 100, 2003, 1028-1033.
    Supplementary Information
    Data analyzed in the paper
  • [75] Reinhard M., Müller T., Guschlbauer B., Timmer J., Hetzel A.
    Transfer function analysis for clinical evaluation of dynamic of cerebral autoregulation - a comparison between spontaneous and respiratory-induced oscillations. Physiological Measurement 24, 2003, 27-45.
  • [74] Horbelt W., Timmer J., Bünner M., Meucci R., Ciofini M.
    Dynamical modelling of measured time series from a Q-switched CO_2 laser. Chaos, Solitons & Fractals 17, 2003, 397-404
  • [73] Kopitzki K., Saparin P., Kurths J., Warnke P., Timmer J.
    Comment on ''Kullback-Leibler and renormalized entropies: Application to electroencephalograms of epileptic patients'' Phys. Rev. E 66, 2002, 043902
  • [72] Horbelt W., Voss H.U., Timmer J.
    Parameter estimation in nonlinear delayed feedback systems from noisy data. Phys. Lett. A 299, 2002, 513-521
  • [71] Müller T.G., Timmer J.
    Fitting parameters in partial differential equations from partially observed noisy data. Physica D 171 , 2002, 1-7
  • [70] Altenburger R., Heitz C., Timmer J.
    Analysis of phase resolved partial discharge patterns of voids based on a stochastic process approach. J. Physics D: Applied Physics 35, 2002, 1149-1163
  • [69] Köster B., Deuschl G., Lauk M., Timmer J., Guschlbauer B., Lücking C.H.
    Essential tremor and cerebellar dysfunction: Abnormal ballistic movements. J. Neurology, Neurosurgery, Psychiatry 73 , 2002, 400-405
  • [68] Walkenhorst O., Luther J., Reinhart Ch., Timmer J.
    Dynamic annual indoor illuminance simulations based on one-hour and one-minute means of irradiance data. Solar Energy 72, 2002, 385-395
  • [67] Steltner H., Staats R., Timmer J., Vogel M., Guttmann J., Matthys H., Virchow J.C.
    Diagnosis of sleep apnea based on automatic analysis of nasal pressure and forced oscillation impedance. Am. J. Resp. Crit. Care Med. 165, 2002, 940-944. Supplement
  • [66] Kristeva-Feige R., Fritsch Ch., Timmer J., Lücking C.H.
    Influence of distraction of attention and precision level of exerted force on beta range EEG-EMG synchronization during maintainted motor contraction task. Clin. Neurophys. 113, 2002, 124-131
  • [65] The Y.-K., Wagner M., Timmer J.
    Method Independent Effects in Testing for Detailed Balance in Ion Channels Gating. Biophys. J. 82, 2002, 2275-2276
  • [64] Müller T., Noykova N., Gyllenberg M., Timmer J.
    Parameter identification in a dynamical model of anaerobic waste water treatment processes. Math. Biosciences 177-178, 2002, 147-160
  • [63] Noykova N., Müller T., Gyllenberg M., Timmer J.
    Quantitative analysis of anaerobic wastewater treatment processes: identifiability and parameter estimation. Biotech. & Bioeng. 78, 2002, 89-103
  • [62] Raethjen J., Lindemann M., Dümpelmann M., Wenzelburger R., Stolze H., Pfister G., Elgar C., Timmer J., Deuschl G.
    Corticomuscular coherence in the 6-15 Hz band. Does the central component of physiological tremor originate from the cortex? Exp. Brain. Res. 142, 2002, 32-40
  • [61] Michalek S., Wagner M., Vach W., Timmer J.
    Finite size properties of maximum likelihood estimators and likelihood ratio tests in Hidden Markov Models. Biometrical J. 43, 2001, 863-879
  • [60] Lindemann M., Raethjen J., Timmer J., Deuschl G., Pfister G.
    Delay estimation for cortico-peripheral relations. J. Neuroscience Methods 111, 2001, 127-139
  • [59] Lauk M., Timmer J., B. Guschlbauer, Hellwig B. Lücking C.H.
    Variability of frequency and phase between antagonistic muscle pairs in pathological human tremors. Muscle & Nerve 24, 2001, 1365-1370
  • [58] Horbelt W., Timmer J., Bünner M.J., Meucci R., Ciofini M.
    Identifying physical properties of a C02 laser by dynamical modeling of measured time series. Phys. Rev. E 64, 2001, 016222
  • [57] Steltner H., Vogel A., Sorichter S., Guttmann J., Matthys H., Timmer J.
    Analysis of forced expired volume signals using multiexponential functions. Med. & Biol. Eng. & Comp. 39, 2001, 190-194
  • [56] Hellwig B., Häußler S., Schelter B., Lauk M., Guschlbauer B., Timmer J., Lücking C.H.
    Tremor-correlated cortical activity in essential tremor. The Lancet 357, 2001, 519-523
  • [55] Wagner M., Timmer J.
    Model selection in non-nested Markov models for ion channel gating J. Theo. Biol. 208, 2001, 439-450
  • [54] Timmer J., Rust H., Horbelt W., Voss H.U.
    Parametric, nonparametric and parametric modeling of a chaotic circuit time series. Phys. Lett. A 274, 2000, 123-134
  • [53] Wagner M., Timmer J.
    The effects of non-identifiability on testing for detailed balance in aggregated Markov models of ion-channel gating. Biophys. J. 79, 2000, 2918-2924
  • [52] Timmer J.
    What can be inferred from surrogate data testing? Phys. Rev. Lett. 85, 2000, 2647
  • [51] Reisch S., Timmer J., Steltner H., Rühle K.H., Ficker J.H., Guttmann J.
    Detection of obstructive sleep apnea by analysis of phase angle signal using the forced oscillation signal. Respiration Physiology 123, 2000, 87-99
  • [50] Reisch S., Daniuk J., Steltner H., Timmer J., Rühle K.H., Geiger K., Guttmann J.
    Detection of different disordered breathing pattern with the forced oscillation technique compared to 3 polysomnographic signals. Respiration 67, 2000, 518-525
  • [49] J. Timmer, M. Lauk, S. Häußler, V. Radt, B. Köster, B. Hellwig, B. Guschlbauer, C.H. Lücking, M. Eichler, G. Deuschl
    Cross-spectral analysis of tremor time series. Int J Bif Chaos 10, 2000, 2595-2610
  • [48] Timmer J.
    Parameter estimation in nonlinear stochastic differential equations. Chaos, Solitons & Fractals 11, 2000, 2571-2578
  • [47] S. Michalek, M. Wagner, and J. Timmer.
    Maximum approximate likelihood estimator for MA-filtered hidden Markov models. IEEE Trans Signal Proc 48, 2000, 1537-1547
  • [46] B. Hellwig, S. Häussler, M. Lauk, B. Köster, B. Guschlbauer, R. Kristeva-Feige, J. Timmer, and C.H. Lücking.
    Tremor-correlated cortical activity detected by electroencephalography. Electroencephalography and Clinical Neurophysiology 111 2000, 806-809
  • [45] Timmer J., Häußler S., Lauk M., Lücking C.H.
    Pathological tremors: Deterministic chaos or nonlinear stochastic oscillators ? Chaos 10, 2000, 278-288
    Data analyzed in this paper
  • [44] Müller T., Ball T., Kristeva-Feige R., Mergner T., Timmer J.
    Selecting relevant electrode positions for classification tasks based on the electro-encephalogram. Medical & Biological Engineering & Computing 38, 2000, 62-67
  • [43] Timmer J., Schwarz U., Voss H.U., Wardinski I., Belloni T., Hasinger G., van der Klis M., Kurths J.
    Linear and nonlinear time series analysis of the black hole candidate Cygnus X-1. Phys. Rev. E 61, 2000, 1342-1352
  • [42] Michalek S., Timmer J.
    Estimating rate constants in Hidden Markov Models by the EM algorithm. IEEE Trans. Signal Proc. 47, 1999, 226-228
  • [41] König M., Paunzen E., Timmer J.
    On the irregular behaviour of the variable star R Scuti. Monthly Notices Royal Astronomical Society 303, 1999, 297-300
  • [40] Timmer J., Lauk M., Vach W., Lücking C.H.
    A test for a difference between spectral peak frequencies. Comp Stat Data Analysis 30, 1999, 45-55
  • [39] Köster B., Lauk M., Timmer J., Poersch M., Guschlbauer B., Glocker F.X., Deuschl G., Lücking C.H.
    Involvement of cranial muscles in orthostatic tremor. Ann. Neur. 45, 1999, 384-388
  • [38] Lücking C.-H., Köster B., Guschlbauer B., Lauk M., Timmer J.
    Parkinsonian and essential tremor: Different entities or different manifestations of the same disorder ? Advances in Neurology 80, 1999, 335-339
  • [37] Lauk M., Timmer J., Lücking C.H., Honerkamp J., Deuschl G.
    A software for recording and analysis of human tremor. Computer Methods and Programs in Biomedicine 60, 1999, 65-77
  • [36] Reisch S., Steltner H. Renotte C., Timmer J., Guttmann J.
    Early detection of upper airway obstruction by analysis of acoustical respiratory input impedance. Biolog. Cybern. 81, 1999, 25-37
  • [35] Glocker F.X., Lauk M., Föll D., Köster B., Guschlbauer B., Timmer J., Deuschl G., Lücking C.H.
    Classical conditioning of the electrically elicited blink reflex in humans: A new method of data analysis. J. Neuroscience Methods 89, 1999, 133-140
  • [34] S. Michalek, H. Lerche, M. Wagner, N. Mitrovic, M. Schiebe, F. Lehmann-Horn and J. Timmer.
    On identification of sodium channel gating schemes using moving-average filtered hidden Markov models. Europ. Biophys. J. 28, 1999, 605-609
  • [33] M. Wagner, S. Michalek, and J. Timmer.
    Estimating rate constants in aggregated Markov models of ion channel gating with loops and with with nearly equal dwell times. Proc. Roy. Soc. B 266, 1999, 1919-1926
  • [32] Lauk M., Köster B., Timmer J., Guschlbauer B., Deuschl G. and Lücking C.H.
    Side-to-side correlation of muscle activity in physiological and pathological human tremors. Electroencephalography and Clinical Neurophysiology 110, 1999, 1774-1783
  • [31] Köster B., Lauk M., Timmer J., Winter T., Guschlbauer B. Glocker F.X., Danek A., Deuschl G., Lücking C.H.
    Central mechanisms in human enhanced physiological tremor. Neuroscience Letters 241, 1998, 135-138
  • [30] Gezeck S., Timmer J.
    Detecting multimodality in Saccadic reaction time distributions in gap and overlap tasks., Biolog. Cybern. 78, 1998, 293-305
  • [29] Timmer J., Lauk M., Pfleger W., Deuschl G.
    Cross-spectral analysis of physiological tremor and muscle activity. I: Theory and application to unsynchronized EMG. Biolog. Cybern. 78, 1998, 349-357
  • [28] Timmer J., Lauk M., Pfleger W., Deuschl G.:
    Cross-spectral analysis of physiological tremor and muscle activity. II: Application to synchronized EMG. Biolog. Cybern. 78, 1998, 359-368
  • [27] Timmer J., Müller T., Melzer W.
    Numerical methods for the determination of calcium release from calcium transients in muscle data. Biophys. J. 74, 1998, 1694-1706
  • [26] Timmer J.
    The power of surrogate data testing with respect to non-stationarity. PRE 58, 1998, 5153-5156
  • [25] Kopitzki K., Warnke P., Timmer J.
    Quantitative analysis by renormalized entropy of invasive electroencephalograph recordings in focal epilepsy. PRE 58, 1998, 4859-4864
  • [24] Timmer J.
    Modeling noisy time series: Physiological tremor. Int. J. Bif. Chaos 8, 1998, 1505-1516
  • [23] Reisch S., Schneider M., Timmer J., Geiger K., Guttmann J.
    Evaluation of forced oscillation technique for early detection of airway obstruction in sleep apnea: a model study . Tech. Health Care 6 , 1998, 245-257
  • [22] Klein S., Timmer J., Honerkamp J.
    Analysis of multichannel patch clamp recordings by Hidden Markov Models. Biometrics 53, 1997, 870-884
  • [21] Timmer J., Klein S.
    Testing the Markov condition in ion channel recordings. Phys. Rev. E 55, 1997, 3306-3310
  • [20] König M., Friedrich S., Staubert R., Timmer J.
    The Seyfert Galaxy NGC 6814 -- a highly variable X-ray source , Astronomy and Astrophysics 322. 1997, 747-750
  • [19] Gezeck S., Fischer B., Timmer J.
    Saccadic reaction times: a statistical analysis of multimodal distributions. Vision Research 37, 1997, 2119-2131
  • [18] König M., Timmer J.
    Analyzing X-ray variability by Linear State Space Models. Astronomy and Astrophysics, SS 124, 1997, 589-596
  • [17] Timmer J., Lauk M., Lücking C.H.
    Confidence regions for spectral peak frequencies. Biometrical J. 39, 1997, 849-861
  • [16] Timmer J., Weigend A.
    Modeling volatility using state space models. Int. J. Neur. Syst. 8, 1997, 385-398
  • [15] Heitz C., Timmer J.
    Using Optimized Time-Frequency Representations for Acoustic Quality Control of Motors. Acta Acoustica 83, 1997, 1053-1064
  • [14] S. Lauer, J. Timmer, D. van Calker, D. Maier, J. Honerkamp
    Optimal weighed Bayesian design applied to dose-response-curve analysis. Communications in Statistics - Theory and Methods 26, 1997, 2879-2903
  • [13] G. Deuschl, P. Krack, M. Lauk, J. Timmer
    Clinical neurophysiology of tremor. Journal of Clinical Neurophysiology 13, 1996, 110-121
  • [12] Gebicke-Härter P., Christoffel F., Timmer, J., Norhoff H., Berger M., van Calker D.
    Both Adenosine A1- and A2-receptors are required to stimulate microglial proliferation, Neurochemistry International 29, 1996, 37-42
  • [11] Weyerbrock A., Timmer J., Hohagen F., Berger M., Bauer J.
    Effects of light and chronotherapie on human circadian rhythm in delayed sleep phase syndrom (DSPS): cytokines, cortisol, growth hormone and the sleep-wake cycle, Biological Psychiatry 40, 1996, 794-797
  • [10] J. Timmer, M. Lauk, G. Deuschl
    Quantitative analysis of tremor time series , Electroencephalography and Clinical Neurophysiology 101, 1996, 461-468
  • [9] M. Bohus, U. Förstner, C. Kiefer, P. Gebicke-Härter, J. Timmer, G. Spraul, H. Wark, H. Hecht, M. Berger, D. van Calker
    Increased sensitivity of the inositol-phospholipid system in neutrophils from patients with acute Major Depressive episodes, Psychiatry Research 65, 1996, 45-61
  • [8] Krieger S., Timmer J., Lis S., Olbrich H.M.
    Some considerations on the Interpretation of Event-Related-Potentials, Journal of Neural Transmission 99, 1995, 103-129
  • [7] Deuschl G., Lauk M., Timmer J.
    Tremor Classification and Tremor Time Series Analysis, Chaos 5, 1995, 48-52
  • [6] Timmer J., König, M.
    On generating power law noise , Astronomy and Astrophysics, 300, 1995, 707-710
  • [5] Bauer J., Hohagen F., Elbert T., Timmer J., Ganter U., Krieger S., Lis S., Postler E., Voderholzer U., Berger M.
    Interleukin-6 Serum Levels in Healthy Persons correspond to the Sleep-Wake-Cycle, Clinical Investigator 72, 1994, 312
  • [4] Jedynak A., Bach M., Timmer J.
    Failure of Dimension Analysis in a simple Five-Dimensional System, Phys. Rev. E 50, 1994, 1770-1780
  • [3] Timmer, J., Gantert, C., Deuschl, G., Honerkamp, J.
    Characteristics of Hand Tremor Time Series, Biol. Cybern. 70, 1993, 75-80
  • [2] Hohagen F., Timmer J., Weyerbrock A., Fritsch-Monero R., Ganter U., Krieger S., Berger M., Bauer J.:
    Cytokine Production during Sleep and Wakefulness and its Relationship to Cortisol in Healthy Humans, Neuropsychobiology 28, 1993, 9-16
  • [1] Gantert C., Honerkamp J., Timmer J.:
    Analysing the dynamics of hand tremor time series , Biol. Cybern. 66, 1992, 479-484

 

Book and conference contributions, abstracts, complete until 2000

  • N. Noykova, T. Müller, M. Gyllenberg, J. Timmer: Identifiability problems in a mathematical model of anaerobic digestion, Int. Conf. Automatics and Informatics, A-37-40, 2001
  • Steltner H., Staats R., Timmer J., Virchow J. C., Matthys H., Guttmann J.: Diagnosis of sleep-disordered breathing based on automatic analysis of nasal pressure and forced oscillation impedance, Proceedings of the International Federation for Medical & Biological Engineering, IX Mediterranean Conference on Medical and Biological Engineering and Computing, 390-393, 2001
  • Steltner H., Staats R., Timmer J., Virchow J. C., Matthys H., Guttmann J.: Automatische Diagnose schlafbezogener Atmungsstörungen durch Analyse von Resistooszillometrie und Maskendruck, Somnologie 5, 52, 2001
  • Timmer J., Wagner M.: Modelling ion channel time series by Hidden Markov Models, in: Trends in Statistical Modelling (Eds.: B. Klein, L. Korsholm), 2001, 67-78
  • Timmer J., Rust H., Horbelt W., Voss H.U.: Identification of a nonlinear circuit, GAMM Conference 2001, in press
  • Lauk M., Timmer J., Lücking C.H., Deuschl G., Honerkamp J.: An application for the analysis of human tremor time-series, in ''Mathematik - Schlüsseltechnologie für die Zukunft'', Springer, Heidelberg, 2000
  • Walkenhorst O., Reinhart C. Timmer J.: Jahressimulation des Tageslichtangebotes in Gebäuden auf der Basis von minütlichen und stündlichen Strahlungsdaten, 7. Symposium Innovative Lichttechnik in Gebäuden, Staffelstein, 2000
  • Steltner H, Vogel M, Timmer J, Sorichter S, Guttmann J: "Modeling of forced expired volume signals using multiexponential functions", Proceedings of the World Congress on Medical Physics and Biomedical Engineering in Chicago, 2000 (On CD-ROM)
  • Staats R, Steltner H, Sorichter S, Timmer J, Matthys H, Guttmann J, Virchow JC: Apnoeanalyse mittels kardiogener Oszillationen und Resistooszillometrie, Somnologie 4, 25-26, 2000
  • Steltner H, Staats R, Timmer J, Virchow JC, Matthys H, Guttmann J: Automatische Klassifikation von Schlafapnoen durch Analyse von Atemwegsimpedanz und Maskendruck, Somnologie 4, 60, 2000
  • Steltner H, Staats R, Vogel M, Timmer J, Virchow C, Matthys H, Guttmann J: Klassifizierung von Schlafapnoen auf der Basis von nasalem Druck und Atemwegsimpedanz, Biomedizinische Technik 45, 440-441, 2000
  • Steltner H, Vogel M, Timmer J, Sorichter S, Guttmann J, Matthys H: Analysis of forced expired volume signals using multiexponential functions, European Respiratory Journal (Suppl), 2000
  • Steltner H, Staats R, Vogel M, Timmer J, Virchow C, Matthys H, Guttmann J: Automatic detection and classification of sleep-disordered breathing using nasal pressure and forced oscillation impedance, European Respiratory Journal 16, 453s, 2000
  • Müller T., Ball T., Kristeva-Feige R., T. Mergner, Timmer J.: Classification of electro-encephalographic spatial patterns, ISMDA-Proceeding, Lecture Notes in Computer Science 1933, Springer, 2000, 55-60
  • H. Steltner, R. Staats, M. Vogel, J. Guttmann, Timmer J: Detection and classification of sleep-disordered breathing using acoustic respiratory input impedance and nasal pressure, ISMDA-Proceeding, Lecture Notes in Computer Science 1933, Springer, 2000, 61-66
  • W. Horbelt, T. Müller, J. Timmer, W. Melzer, and K. Winkler: Analysis of Nonlinear Differential Equations: Parameter Estimation and Model Selection, ISMDA-Proceeding, Lecture Notes in Computer Science 1933, Springer, 2000, 152-158
  • Rust H., Timmer J., Horbelt W. Voss H.: Parametric, nonparametric and parametric modelling of a chaotic circuit time series, NOLTA-Proceedings Vol.2, 713-716, 2000
  • M. Lindemann, J. Raethjen, J. Timmer, G. Deuschl, G. Pfister: Robust Delay Estimation applied to Cortical and Peripheral Signals. Brain Topography, 2000
  • Swameye I., Mueller T., Timmer J., Sandra O., Klingmueller U.: Properties of a signalling pathway revealed by dynamical modelling. BLOOD 96, 2000, 4306
  • Timmer J., Horbelt W., Rust H.:
    Estimating parameters in ODEs with application to the first example of the Y2k Benchmarks of Predictability. EGS 2000
  • Timmer J., Horbelt W., Rust H., Voss H.:
    Parametric and non-parametric modeling of time series with application to the second example of the Y2k Benchmarks of Predictability. EGS 2000
  • Timmer J., Häußler S., Lauk M., Lücking C.-H.
    Pathological tremors: Deterministic chaos or nonlinear stochastic oscillators? in D.S. Broomhead, E.A. Luchinskaya, P.V.E. Clintock and T. Mullin, ed., Stochaos: Stochastic and Chaotic Dynamics in the Lakes , American Institute of Physics, Melville, NY, USA, 2000, 197-202
  • Timmer J., Horbelt W., Bünner M., Ciofini M., Meucci R.
    Estimating Parameters in Differential Equations with Application to Laser Data. in D.S. Broomhead, E.A. Luchinskaya, P.V.E. McClintock and T. Mullin, ed., Stochaos: Stochastic and Chaotic Dynamics in the Lakes , American Institute of Physics, Melvilley, NY, USA, 2000, 617-623
  • Timmer J.
    Denoising time series by the Kalman filter. Geophysical Research Abstracts 1, 788, 1999
  • Hellwig B., Häußler S., Lauk M., Guschlbauer B., Köster B., Kristeva-Feige R., Timmer J., Luecking C.H.
    Tremor-correlated cortical activity in essential tremor detected by electroencephalography Clinical Neurophysiology 110 , 180, 1999
  • Wagner M., Michalek S., Timmer J.
    Testing for the number of states in Hidden Markov models with application to ion channel data in: Studies in classification, data analysis and knowledge organization, W. Gaul, H. Locarek-Junge (Eds.) GfKL-Proceedings, Dresden, Springer, 1999, 260-267
  • Wagner M., Lauk M., Timmer J.
    Doppelblattkontrolle -- Steigerung der Zuverlässigkeit von Kuvertiermaschinen In: VDI Statusseminar ''Technische Anwendungen von Erkenntnissen der Nichtlinearen Dynamik'', 1999, 251-254
  • Horbelt W., Timmer J., Honerkamp J., Bünner M.
    Estimating parameters in nonlinear differential equations with application to Q-switched lasers In: VDI Statusseminar ''Technische Anwendungen von Erkenntnissen der Nichtlinearen Dynamik'', 1999, 311-314
  • Michalek S., Wagner M., Timmer J.
    New maximum approximate likelihood estimators for moving-average filtered hidden Markov models In: Prague Stochastics, Eds. M. Huskova, P. Lachout, J.A. Visek. 1999
  • Wagner M., Michalek S., Timmer J.
    Hidden Markov Models applied to single ion channel recordings Proc. of 52nd Session of the International Statistical Institute, 1999
  • Müller T., Horbelt W., Timmer J.:
    Analysis of non-linear dynamical systems: estimating parameters and model selection, Theory and Mathematics in Biology and Medicine, Amsterdam, 1999, 355
  • Müller T., Winkler K., Timmer J.:
    Parameter estimation and model selection in ODEs, Equadiff 99, Berlin, 269-270
  • Steltner H., Timmer J., Guttmann J.:
    Acoustical respiratory input impedance with compliant upper airway walls and pharyngeal obstruction: a mathematical model study, Medical and Biological Engineering & Computing 37, 1198-1199, 1999
  • Steltner H., Timmer J., Guttmann J.:
    Acoustical imput impedance, an early indicator of obstructive sleep apneas: a theoretical study, Sleep Research Online 2, 447, 1999
  • Timmer J., Wardinsky I., Schwarz U., Hasinger G., Kurths J.:
    Linear and non-linear time series analysis of Cyg X-1, Annales of Geophysics, Suppl IV 16, 1998, C1098
  • Horbelt W., Timmer J., Melzer W.:
    Estimating parameters in nonlinear differential equations with application to physiological data
    Proc. 2nd Int. Conf. Differential Equations and Applications, St. Petersburg, Ed. G. Osipenko, 1998, p.23-33 Timmer J., Weigend A.:
    Modeling volatilities using the state space model In: Decision Technologies for Computational Finance, edited by A.-P. N. Refenes, A. N. Burgess, and J. E. Moody (Proceedings of the Fifth International Conference Computational Finance, London, December 1997), p. 233-246. Dordrecht: Kluwer, 1998
  • Michalek S., Lerche H, Mitrovic N., Schiebe M., Lehmann-Horn F., Timmer J.:
    Generalized Hidden Markov Models considering correlated noise and filtering for analyzing sodium channel recordings
    Biophys. J. 74, A321, 1998
  • Michalek S., Lerche H, Mitrovic N., Schiebe M., Lehmann-Horn F., Timmer J.:
    Generalized Hidden Markov Models considering correlated noise and filtering for analyzing sodium channel recordings
    Deutsche und Skandinavische Physiologische Gesellschaft, Hamburg, 1998
  • Köster B., Lauk M., Timmer J., Guschlbauer B., Glocker, F.X., Lücking CH.:
    Involvement of a transcortical pathway in Parkinsonian postural and resting tremor: a study in a Parkinsonian patient with congenital mirror movements , Electroencephalography and Clinical Neurophysiology 107, 1998, 66
  • Reisch S., Steltner H., Renotte C., Timmer J., Geiger K., Guttmann J.:
    Verlauf der akustischen Atemwegsimpedanz bei simulierter Obstruktion der oberen Atemwege, Biomedizinische Technik
    Biomedizinische Technik, 43 (Suppl 1), 306-307, 1998
  • Hellwig B. Häussler S. Lauk M., Guschlbauer B., Köster B., Kristeva-Feige R., Timmer J., Lücking C.H.:
    Tremor-related EEG activity in patients with Parkinsonian disease. Electroenceph. clin. Neurophys. 107, 46P, 1998
  • Kopitzki K., Timmer J., Warnke P.C.:
    Spatial Measurement of blood-brain-barrier permeability. Acta Neurochir 140, 871-872, 1998
  • König M., Staubert R., Timmer J.:
    Analyzing X-ray variability by State Space Models, in: D.Maoz et al (eds.), Astronomical Time Series, 265-268, 1997, Kluwer Academic Publishers
  • Michalek S., Lerche H, Mitrovic N., Schiebe M., Lehmann-Horn F., Timmer J.:
    Identification of gating schemes of wild type and mutant sodium channels from single channel recordings using Hidden Markov models, Pflug. Arch. 433, 1997, 505
  • Köster B., Lauk M., Timmer J., Lücking CH.:
    Side-to-side correlation of pathological tremors, Electroencephalography and Clinical Neurophysiology 103, 1997, 211
  • Haan H., Timmer J., Mathar R., Krüger J.:
    Multidimensional scaling: Analyzing multineural spike patterns. R.Klar, O.Opitz (Eds.): Classification and Knowledge Organisation, 15-19, Springer, 1997
  • Michalek S., Lerche H, Mitrovic N., Schiebe M., Lehmann-Horn F., Timmer J.:
    Identification of gating schemes of wild type and mutant sodium channels from single channel recordings using Hidden Markov models, Biophys. J. 72, 1997, A117
  • Reisch S., Timmer J., Rühle K-H., Geiger K., Guttmann J.:
    Detektion von obstruktiven Schlafapnoen durch statistische Analyse der Phasenwinkelveränderungen der Atemwegsimpedanz, Biomedizinische Technik 42, Ergänzungsband 2, 295-296, 1997
  • Vibe-Rheymer K., Timmer J., Vesin J.M.:
    On a method for investigating long-range correlations, 1997 IEEE Workshop on Nonlinear Signal and Image Processing, Michigan
  • Timmer J., Heitz, C.: Akustische Qualitätskontrolle von Elektromotoren mit Zeitfrequenzverteilungen , Workshop Zeitreihenanalyse, 51-54, VDI, 1997
  • Michalek S., Timmer J., Lerche H., Schiebe M.:
    A new method for an automatic leak current removal during voltage jump experiments on patch-clamped voltage gated ion channels. Pflügers Arch 431 , 1996, R91
  • Köster, B., M. Lauk, M. Poersch, J. Timmer, B. Guschlbauer, F.X. Glocker, G. Deuschl, C.H. Lücking:
    Primary Orthostatic Tremor: Subclinical Involvement of cranial Muscles, Electroencephalography and Clinical Neurophysiology 99, 1996, 372
  • H. Haan, J.Timmer, J. Krüger. Explorative data analysis by Multidimensional Scaling. in N. Elsner and H.-U. Schnitzler, Göttingen Neurobiology Report. Thieme Verlag, 1996
  • H. Haan, J. Timmer, I. Bondar, J. Krüger Local field potentials (LFPs) and spikes in monkey striate cortex. in N. Elsner and H.-U. Schnitzler, Göttingen Neurobiology Report. Thieme Verlag, 1996
  • Köster, B., M. Lauk, J. Timmer, T. Winter, B. Guschlbauer, F.X. Glocker, G. Deuschl, C.H. Lücking:
    Involvement of Central Pathways in Enhanced Physiological Tremor, Electroencephalography and Clinical Neurophysiology 99, 1996, 371
  • König M., Timmer J.:
    Analyzing X-ray variability by Linear State Space Models, in: Babu J.G., Feigelson E.D. (eds.) Statistical challenges in modern astronomy II, 1996, 393-394
  • Michalek S., Lerche H., Mitrovic N., Schiebe M., Lehmann-Horn F., Timmer J.:
    Identifizierung von Gating-Schemata aus Patch-Clamp Messungen von Na Kanälen mit Hilfe von Hidden-Markov-Modellen. Biomedizinische Technik 41, Ergänzungsband 1, 336-337, 1996
  • Huber W., Kopitzki K., Timmer J. Warnke P.:
    Ortsaufgelöste Messung und Modellierung der Permeabilität der Blut-Hirn-Schranke. Biomedizinische Technik 41, Ergänzungsband 1, 160-161, 1996
  • Reisch S., Kulstrunk M., Timmer J., Schneider M., Rühle K.H., Geiger K., Gutmann J.:
    Physikalisches Modell zur Simulation von Zeitverläufen der Atemwegsimpedanz bei obstruktiver Schlafapnoe. Biomedizinische Technik 41, Ergänzungsband 1, 84-85, 1996
  • Reisch S., Renotte C., Timmer J., Honerkamp J., Geiger K., Gutmann J.:
    Theoretische Evaluierung der Resisto-Oszillometrie bei obstruktiver Schlafapnoe. Biomedizinische Technik 41, Ergänzungsband 1, 108-109, 1996
  • Michalek S., Lerche H, Mitrovic N., Schiebe M., Lehmann-Horn F., Timmer J.: Identification of gating schemes of wild type and mutant sodium channels from using Hidden Markov models, 3rd European Conference on Mathematics Applied to Biology and Medicine, 1996, p.212
  • Deuschl G., Timmer J., Genger H., Gantert C., Lücking C.H., Honerkamp J.:
    Frequency, amplitude and waveform characteristics of physiologic and pathologic tremors, In: Quantitative methods and scoring in extrapyramidal disorders. H. Przuntek, P. H. Kraus, P. Klotz, A.D. Korczyn (Hrsg.) Springer, Heidelberg 1995, p. 93-100
  • Timmer J.:
    Vorverarbeitung, Modellierung und Klassifikation von Zeitreihen, Verlag Harri Deutsch, 1995
  • Haan H., Timmer J., Krüger J.:
    Multineuronal Spike Patterns: Visualization of relationships by Multidimensional Scaling, in N. Elsner, R. Menzel (Ed.): Learning and Memory. Georg Thieme Verlag, 1995, 475
  • Deuschl G., Lauk M., Timmer J.:
    Tremor Classification and Tremor Time Series Analysis, In: Belair J, Glass L, an der Heiden U, Milton J(eds). Dynamical Disease. Mathematical Analysis of Human Illness. AIP Press, (1995).
  • Gezeck S., Timmer J.:
    Detecting Multimodality in Saccadic Reaction Time Distributions, Proceedings of the 8. European Conference on Eye Movements, 1995, pp. 66-67
  • Timmer J.:
    Hidden Markov Models of ion channels, Neuromuscular Disorders, ENMC, 1995
  • Krieger S., Tritschler B., Lis S., Timmer J., Hohagen F. Berger M.:
    Cholinerge Modulation von REM - Schlaf: Entwicklung eines spektralanalytischen Untersuchungsverfahrens, In: Schlafmedizin, Gustav Fischer Verlag, 1993
     

 

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