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Michael Frotscher


Principal Investigator in


Research Topics

  • hippocampal circuitry
  • role of reelin in neural migration
  • neuronal survival after lesion
  • fine structure of synapses



Academic Background

  • 1981: Habilitation: University of Frankfurt/Main
  • 1974: Dr. med., Humboldt University Berlin


Research Positions

  • 1989 - present: Professor and Chairman, Institute of Anatomy, University of Freiburg
  • 1985: Visiting Professor, Dept. of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, USA
  • 1983 - 1989: Associate Professor, Institute of Anatomy, University of Frankfurt/Main
  • 1982: Assistant Professor, Institute of Anatomy, University of Heidelberg
  • 1979 - 1981: Research Assistant, Max-Planck-Institute for Brain Research, Frankfurt/Main
  • 1974: Postdoc, 1st Dept. of Anatomy, Semmelweis University Budapest, Hungary
  • 1974 - 1979: Scientific Assistant, Institute of Anatomy, Humboldt University Berlin, EastGermany


Scientific Honors, Editorial Boards, Other Scientific Activities

  • 2002: Ernst Jung Award for Medical Research
  • 2001: Landesforschungspreis Baden-Württemberg
  • 2000: Max Planck Award for International Cooperation
  • 1999: President of the German Anatomical Society
  • 1998: Feldberg Award (Feldberg Foundation for Anglo-German Scientific Exchange)

  • 1993: President of the German Neuroscience Society (NWG)
  • 1993: Leibniz Preis of the Deutsche Forschungsgemeinschaft
  • 1992: Wolfgang Bargmann Preis of the Anatomische Gesellschaft
  • Member of the following editorial boards: J. Neurosci., J. Comp. Neurol., Neuroscience, Eur. J. Neurosci., Exp. Neurol., J. Neurocytol., Hippocampus, Exp. Brain Res., Anat. Embryol., Restor. Neurol. Neurosci., Cell Tissue Res., Cells Tissues Organs



  • Bender R.A., Kirschstein T., Kretz O., Brewster A.L., Richichi C., Rüschenschmidt C., Shigemoto R., Beck H., Frotscher M., Baram T.Z.: Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation J Neurosci, 2007; 27 (17) : 4697-4706

  • Bouzioukh F., Wilkinson G.A., Adelmann G., Frotscher M., Stein V., Klein R.: Tyrosine Phosphorylation Sites in ephrinB2 Are Required for Hippocampal Long-Term Potentiation But Not Long-Term Depression. J Neurosci, 2007; 27 (42) : 11279-11288

  • Frotscher M:, Zhao S., Förster E.: Development of cell and fiber layers in the dentate gyrus Prog Brain Res, 2007; 163: 133-142

  • Hack I., Hellwig S., Junghans D., Brunne B., Bock H.H., Zhao S., Frotscher M.: Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. Development, 2007; 134: 3883-3891 

  • Rollenhagen A., Sätzler K., Rodriguez E.P., Jonas P., Frotscher M., Lübke J.H.R.: Structural Determinants of Transmission at Large Hippocampal Mossy Fiber Synapses J Neurosci, 2007; 27 (38) : 10434-10444

  • Förster, E., Zhao, S., Frotscher, M. (2006) Laminating the hippocampus. Nat Rev Neurosci, in press.

  • Knöll, B., Kretz, O., Fiedler, C., Albert, S., Schütz, G., Frotscher, M., Nordheim, A. (2006) Serum response factor controls neuronal circuit assembly in the hippocampus. Nat Neurosci 9,195-204.

  • Alberti, S., Krause, S.M., Kretz, O., Philippar, U., Lemberger, T., Casanova, E., Wiebel, F.F., Schwarz, H., Frotscher, M., Schütz, G., Nordheim, A. (2005) Neuronal migration in the murine rostral migratory stream requires serum response factor. Proc Natl Acad Sci USA 102, 6148-6153.

  • Beffert, U., Weeber, E.J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J.D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer , R.E., Herz, J. (2005) Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron 47, 567-579.

  • Grunwald, I.C., Korte, M., Adelmann, G., Plueck, A., Kullander, K., Adams, R.H., Frotscher, M., Bonhoeffer, T., Klein, R. (2004) Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci 7, 33-40.

  • Zhao, S., Chai, X., Förster, E., Frotscher, M. (2004) Reelin is a positional signal for the lamination of dentate granule cells. Development 131, 5117-5125.

  • Frotscher, M., Haas, C.A., Förster, E. (2003) Reelin controls granule cell migration in the dentate gyrus by acting on the radial glial scaffold. Cereb Cortex 13, 634-640.

  • Zhao, S., Förster, E., Chai, X., Frotscher, M. (2003) Different signals control laminar specificity of commissural and entorhinal fibers to the dentate gyrus. J Neurosci 23, 7351-7357.

  • Deller, T., Korte, M., Chabanis, S., Drakew, A., Schwegler, H., Stefani, G.G., Zu­ni­ga, A., Schwarz, K., Bonhoeffer, T., Zeller, R., Frotscher, M., Mundel, P. (2003) Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc Natl Acad Sci USA 100 (2003) 10494-10499

  • Kulik, A., Vida, I., Luján, R., Haas, C.A., López-Bendito, G., Shigemoto, R., Frotscher, M. (2003) Subcellular localization of metabotropic GABAB receptor subunits GABAB1a/b and GABAB2 in the rat hippocampus. J Neurosci 23, 11026-11035.

  • Haas, C.A., Dudeck, O., Kirsch, M., Huszka, C., Kann, G., Pollak, S., Zentner, J., Frotscher, M. (2002) Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. J Neurosci 22, 5797-5802.

  • Förster, E., Tielsch, A., Saum, B., Weiss, K.H., Johanssen, C., Graus-Porta, D., Mül­ler, U., Frotscher, M. (2002) Reelin, Disabled 1, and beta1 integrins are required for the formation of the radial glial scaffold in the hippocampus. Proc Natl Acad Sci (USA) 99, 13178-13183.

  • Förster, E., Zhao, S., Frotscher, M. (2001) Hyaluronan-associated adhesive cues control fiber segregation in the hippocampus. Development 128, 3029-3039.

  • Vida, I., Frotscher, M. (2000) A hippocampal interneuron associated with the mossy fiber system. Proc Natl Acad Sci USA 97, 1275-1280.


Weitere Publikationen: siehe auch in der Forschungsdatenbank der Universität Freiburg oder in Pubmed.

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