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Dominik von Elverfeldt

Faculty


Principal Investigator in

 

Research Topics

  • Preclinical research on rodents

 

Techniques

  • Molecular Imaging
  • Functionalised iron oxide particles
  • 31P MRS on renal grafts

 

CV

Academic Background

  • 2002: Dr. rer. nat. (Ph.D.), Faculty of Chemistry, Pharmacy and Earth Sciences, Albert Ludwig University of Freiburg, Germany. Thesis on Electrophoretic MRI
  • 1996-2002: Ph.D. Student at the Department of Radiology Medical Physics, University Hospital Freiburg, Germany
  • 1989-1995: Study of Physics, Faculty of Physics, Albert Ludwig University of Freiburg, Germany 

 

Research Positions

  • 2005-2006: Assistant Scientist - Department of Radiology Medical Physics, University Hospital Freiburg, Germany
  • Since 2005: Head of Molecular Imaging Research - Department of Radiology Medical Physics, University Hospital Freiburg, Germany

 

Publications

Articles

  • Hagemeyer CE, von Zur Muhlen C, von Elverfeldt D, Peter K.
    Single-chain antibodies as diagnostic tools and therapeutic agents.
    Thrombosis and haemostasis 2009;101(6):1012-1019.
  • Reichardt W, Daniel Romaker, Anne Becker, Martin Buechert, von Elverfeldt D
    Monitoring Kidney and Renal Cyst Volumes applying MR approaches on a Rapamycin treated Mouse Model of ADPKD.
    Magn Reson Mater Phy 2009 June; 22(3): 143-9.
  • Reichardt W, Dürr C, von Elverfeldt D, Jüttner E, Gerlach UV, Yamada M, Smith B, Negrin RS, Zeiser R.
    Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation.
    J Immunol. 2008 Oct 1;181(7):4770-9.
  • von Elverfeldt D*, von zur Muhlen C*, Moeller J, Chodhury R, Paul D, Hagemeyer C, Becker A-K, Neudorfer I, Schwarz M, Bode C, Peter K.
    A magnetic resonance imaging contrast agent targeted towards activated platelets allows in vivo detection of thrombosis and monitoring of thrombolysis.
    Circulation 2008 Jul 15;118(3):258-67
  • Shih Y-Y, Büchert M, Chung H-W, Hennig J, von Elverfeldt D.
    Vitamin C estimation with standard 1H spectroscopy using a clinical 3T MR-system: Detectability and Reliability within the human brain.
    Journal of Magnetic Resonance Imaging 2008 Aug;28(2):351-8
  • Schurigt U, Sevenich L, Vannier C, Gajda M, Schwinde A, Werner F, Stahl A, von Elverfeldt D, Becker AK, Bogyo M, Peters C, Reinheckel T
    Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MTV-PyMT-transgenic mouse model.
    Biological Chemistry, 2008 Aug; 389: 1067-1074
  • Zhong K, Leupold J, von Elverfeldt D, Speck O
    The Molecular Basis for Gray and White Matter Contrast in Phase Imaging.
    Neuroimage 2008 May 1;40(4):1561-6. (in press)
  • Fritsch A, Loekermann S, Kern JS, Braun A, Bösl MR, Bley T, Schumann H, von Elverfeldt D, Paul D, Erlacher M, von Rautenfeld DB, Hausser I, Fässler R, Bruckner-Tuderman L.
    A hypomorphic mouse model for dystrophic epidermolysis bullosa reveals disease mechanisms and responds to fibroblast therapy.
    Journal of Clinical Investigation 2008 May;118(5):1669-79.
  • von Elverfeldt D*, von zur Muhlen C*, Choudhury RP, Ender J, Ahrens I, Schwarz M, Hennig J, Bode C, Peter K.
    A functionaliszed magnetic resonance contrast agent selectively binds to glycoprotein iib/iiia on activated human platelets under flow conditions and is detectable at clinically relevant field strengths.
    Molecular Imaging2008 Mar-Apr;7(2):59-67
  • Stalder AF, von Elverfeldt D, Paul D, Hennig J, Markl M.
    Variable Echo Time Imaging and Signal Characteristics of 1-M Gadobutrol Contrast Agent at 1.5 and 3T.
    Magn Reson Med 2008 jan; 59(1):113-123
  • von Elverfeldt D, Niekisch M, Quaschning T, El Saman A, Kirste G, Kraemer-Guth A, Hennig J.
    Kinetics of PME/Pi in Pig Kidneys during Cold Ischemia
    NMR in Biomedicine 2007 Nov;20(7):652-657
  • von zur Muehlen C, v. Elverfeldt D, Neudorfer I, Steitz B, Petri-Fink A, Hofmann H, Bode C, Peter K
    Superparamagnetic Iron Oxide Binding and Uptake as Imaged by Magnetic Resonance is Mediated by the Integrin Receptor Mac-1 (CD11b/CD18): Implications on Imaging of Atherosclerotic Plaques
    Atherosclerosis 2007 Jul;193(1):102-11.
  • von zur Muehlen C, von Elverfeldt D, Choudhury R, Bode C, Peter K
    A Single-chain Antibody Directed Against Activated Platelets Allows Targeted Magnetic Resonance Imaging of Human Thrombi at Clinically Relevant Field Strengths.
    AHA 2005, Circulation 112 (17) supplement: 1092
  • Niekisch M, von Elverfeldt D, El Saman A, Hennig J, Kirste G.
    "Improved Pretransplant Assessment of Renal Quality via 31P-Magnetic Resonance Spectroscopy Employing Chemical Shift Imaging"
    Transplantation 2004 77(7):1041-1045
  • Bilecen D, Kaspar A, Küstermann E, Seelig J, Elverfeldt D, Scheffler K.
    "Intrahepatic detection of the non-steroidal antirheumatic drug niflumic acid followed by in vivo and in vitro 19F MR spectroscopy in humans."
    NMR Biomed. 2003 May;16(3):144-51
  • P. Berthold, D. Elverfeldt, W. Fiedler, J. Hennig, M.Kaatz, U. Querner
    "Magnetic Resonance Imaging and Spectroscopy (MRI, MRS) of Senonal Patterns of Body Composition: A Methodological Pilot Study in White Storks (Ciconia ciconia)"
    (2001) J. Ornithol. 142, 63-72

 

Conference Abstracts (as first author)

  • von Elverfeldt D, von zur Muhlen C, Möller J, Paul D, Becker A-K, Neubauer I, Bode C, Peter K, J. Hennig
    A MRI Contrast Agent Targeted for Activated Platelets Allows detection of Thrombosis and Thrombolysis in an In Vivo Mouse Model.
    ISMRM 16th Annual Meeting #477 (2008)
  • von Elverfeldt D, Emerich P, Weigel J, Paul D, Steinmann D, Schneider M, Runck M, Stahl C, Gutmann J, Leupold J.
    SSFP based high resolution 19F Imaging of the rat lung ex-vivo with FC84.
    ISMRM 16th Annual Meeting #2642 (2008)
  • Elverfeldt D, Buechert M, Kaufmann R, Huell M, Hennig J.
    "Evidence for Detection of Ascorbic Acid in the Human Brain at 3T"
    ISMRM 14th Annual Meeting #3145 (2006)
  • Elverfeldt D, Buschmann E, Schirmer S, Buechert M, Hennig J.
    "Detection of blood flow reserve in peripheral arterial disease with Muscle-BOLD"
    ESMRMB 21st Annual Meeting #535 (2004)
  • Elverfeldt D, Niekisch M, El Saman A, Hopt U T, Hennig J.
    "Temporal Behaviour of PME/Pi in Pigs´ Kidneys during Cold Ischemic Time"
    ISMRM 11th Annual Meeting #43 (2003)
  • Elverfeldt D, Heinze J, Hennig J.
    ""Electrophoretic CSI using Deuterated Acetonitrile""
    ISMRM 9th and ESMRMB 18th Joint Annual Meeting #1705 (2001)
  • Elverfeldt D, Heinze J, Hennig J.
    "Electrophoretic CSI"
    ESMRMB 17th Annual Meeting #414 (2000)
  • Elverfeldt D, Querner U, Fiedler W, Berthold P, Hennig J.
    Experimental MRI/MRS on Seasonal Fat Deposition During Stork Migration
    ISMRM Proc. 7th Annual Meeting #264 (1999)

 

Dissertation

  • Dominik v. Elverfeldt
    ENMR: Ortsaufgelöste Bestimmung von Migrationsgeschwindigkeiten im elektrischen Feld
    Universität Freiburg 2002, Fakultät für Chemie, Pharmazie und Geowissenschaften (Prof. Heinze) 

 

Diploma Thesis

  • Dominik v. Elverfeldt
    Numerische Simulationen zur Quantifizierung von in vivo 1H NMR Spektren
    Universität Freiburg 1995, Fakultät für Physik (Prof. Runge)

 

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