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Clemens Boucsein

Faculty


Principal Investigator in

 

Research Topics

  • Impact of network activity on neuronal cell physiology and integration characteristics
  • Spike-generating mechanisms
  • Computational neuroscience

 

Techniques

  • Patch-clamp recordings in acute slices and cell culture
  • Dynamic laser-uncaging of caged compounds
  • Calcium imaging in acute slices and cell culture
  • Histological staining techniques
  • Confocal imaging
  • Morphological reconstruction techniques

 

CV

Academic Background

  • 2000 Ph.D., Free University of Berlin, Germany
  • 1995 Diploma for Biology, University of Cologne, Germany
  • 1992 - 1995 Study of Biology, University of Cologne, Germany


Research Positions

  • Since 2008 Assistant Professor, Dept. for Neurobiology and Biophysics, University of Freiburg
  • 2004 - 2007 Work Group Leader, BCCN Freiburg
  • 2002 - 2004 Postdoc, Dept. for Neurobiology and Biophysics, University of Freiburg
  • 2000 - 2001 Postdoc, MDC Berlin
  • 1997 - 2000 Ph.D., MDC Berlin
  • 1996 - 1997 Ph.D. student, Dept. for Experimental Biophysics, Humboldt-University, Berlin
  • 1994 - 1995 Visiting scolar Dept. of Zoology, University of Washington, Seattle, USA

 

 

Publications

Peer Reviewed Articles

  • Kumar A, Vlachos I, Aertsen A and Boucsein C (2013)
    The challenges of understanding brain function by specific manipulation of neuronal sub-populations.
    TiNS (in press).
  • Reimer ICG, Staude B, Boucsein C and Rotter S (2013)
    A newmethod to infer higher-order spike correlations from membrane potentials.
    J Comput Neurosci DOI 10.1007/s10827-013-0446-8.
  • Deger M, Helias M, Boucsein C and Rotter S (2012)
    Statistical properties of superimposed stationary spike trains.
    J Comput Neurosci 32:443–463.
  • Deger M, Helias M, Boucsein C and Rotter S (2012) Statistical properties of superimposed stationary spike trains. J Comput Neurosci 32:443–463.
  • Fucke T, Suchanek D, Nawrot MP , Seamari Y, Heck DH, Aertsen A and Boucsein C (2011)
    Stereotypic spatio-temporal activity patterns during slow-wave activity in the neocortex.
    J Neurophysiology 106: 3035-3044.
  • Boucsein C, Nawrot MP, Schnepel P and Aertsen A (2011) Beyond the cortical column: abundance and physiology of horizontal connections imply a strong role for inputs from the surround. Fornt Neurosci 5 :32.
  • Franke F, Natora M, Boucsein C, Munk MHJ, Obermayer K (2009) Online spike detection and spike sorting capable of instantaneous resolution of overlapping spikes. J Comp Neurosci, DOI 10.1007/s10827-009-0163-5
  • Boucsein C, Tetzlaff T, Meier R, Aertsen A and Naundorf B (2009) Dynamical response properties of neocortical neuron ensembles: Multiplicative versus additive noise. J Neurosci 29 (4): 1006-1010.
  • Nawrot MP, Schnepel P, Aertsen A and Boucsein C (2009) Precisely timed signal transmission in neocortical networks with reliable intermediate-range projections. Frontiers Neural Circuits 3 (1): 1-11.
  • Nawrot MP, Boucsein C, Rodriguez-Molina V, Riehle A, Aertsen A and Rotter S (2008) Measurement of variability dynamics in cortical spike trains J Neurosci. Methods 169, 374-390.
  • Nawrot M, Boucsein C, Rodriguez-Molina V, Gruen S, Rotter S (2007) Serial correlation of inter-spike intervals in cortical neurons in vivo and in vitro. Neurocomputing 70 (10-12): 1717-1722.
  • Kojima H, Boucsein C, Aertsen A and Tsukada M (2006) Rapid focal laser uncaging in acute brain slices. IEEE/OSA J Lightwave Tech. 6:66-74.
  • Boucsein C, Nawrot M, Rotter S, Aertsen A, Heck D (2005) Controlling synaptic input patterns in vitro by dynamic photo stimulation. J Neurophysiol: 94: 2948-2958.
  • Boucsein C, Zacharias R, Farber K, Pavlovic S, Hanisch UK, Kettenmann H (2003) Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro. Eur J Neurosc: 17(11): 2267-76.
  • Schipke CG, Boucsein C, Ohlemeyer C, Kirchhoff F, Kettenmann H (2002) Astrocyte Ca2+ waves trigger responses in microglial cells in brain slices. FASEB J: 16(2): 255-257.
  • Boucsein C, Nolte C. and Kettenmann H (2000) Electrophysiological properties of microglial cells in normal and pathologic rat brain slices. Eur J Neurosc: 12(6): 2049-58.
     

Patents

  • Aertsen A, Boucsein C, Heck D, Nawrot M, Rotter S (2010)
    Dynamic Simultaneous Multisite Photostimulation (DSMP).
    Patent No. EP1762877-B1 (2010-11-17) with European Patent Office (EPO).

 

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