Defects in distal axonal translation in FUS-mediated ALS - Part I
Neurodegenerative diseases have become an increasing problem over the last couple of decades as the average age of population is rising all over the world. One of these is amyotrophic lateral sclerosis (ALS), which affects motor neurons and results in complete loss of an individual's motor function within 3-5 years. About 10% of cases are familial ALS and are thought to be caused by specific genetic mutations, which may lead to an altered RNA metabolism in the distal axon. This master thesis aims at investigating whether this is caused by defects in axonal transport or by an overall altered rate of translation.
The talk is open to the public. Guests are cordially invited!