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You have a new invitation for the Bernstein Seminar on 24 April 2018!
 

April 24, 2018

 
 
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Basic Neurosciences

Université de Genève

 
 
 
 
   
 
 
 

Tuesday, 24 April 2018

 

17:15 h

 

vCal iCal

 

 

Lecture Hall (ground floor)
Bernstein Center Freiburg
Hansastraße 9a
79104 Freiburg

 

Hosted by Carsten Mehring

 
 
 
 
 

Neuroprostheses based on intracortical recordings of neural activity for restoration of movement and communication of people with paralysis

 

Paralysis has a severe impact on a patient’s quality of life and entails a high emotional burden and life-long social and financial costs. Restoring movement and independence for the paralyzed remains a challenging clinical problem, currently with no viable solution. Recent demonstrations of intracortical brain-computer interfaces, neuroprosthetic devices that create a link between a person and a computer based on a person’s brain activity, have brought hope for their potential to restore movement and communication1-9. While the intracortical brain-computer interfaces have steadily improved over the last decade, our recent success in linking brain activity with the newly developed techniques for spinal cord stimulation10-13 look to revolutionize locomotor rehabilitation. Specifically, our brain-spine interface restored weight-bearing locomotion of the paralyzed leg as early as six days post-injury in macaques14. New approaches in identifying neural features and designing decoding algorithms, which transform neural signals into computer commands, aim to deliver both stable and accurate control over clinically relevant periods of several months4. To this end, we developed signal processing and decoder calibration approaches that enabled a person with long-stable tetraplegia to control a communication brain-computer interface for 138 days with an unchanged decoder. Preliminary clinical studies suggest that these concepts and technologies are directly translatable to therapeutic strategies for people with paralysis.

 

Literature

Ajiboye et al. Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration. The Lancet, (2017)(Link)

Wenger et al. Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury. Nat Med 22, 138-145, (2016)(Link)

Capogrosso et al. A brain–spine interface alleviating gait deficits after spinal cord injury in primates. Nature 539, 284-288, (2016).(Link)

 

The talk is open to the public. Guests are cordially invited!

 

 
 
 

          

 
 

                
 
 
 

BERNSTEIN CENTER FREIBURG
Hansastraße 9a
79104 Freiburg im Breisgau
 

Start Date Description Title
Nov 20, 2018 05:15 PM Tuesday, November 20, 2018 | 17:15 h Event Bernstein Seminar | Jan Gläscher | University Medical Center Hamburg-Eppendorf
Dec 06, 2018 05:15 PM Thursday, December 6, 2018 Event Bernstein Seminar | Matthieu Gilson | Universitat Pompeu Fabra, Barcelona
Dec 11, 2018 05:15 PM Tuesday, December 11, 2018 | 17:15 h Event Bernstein Seminar | Nicole Rosskothen-Kuhl | Uinversity Medical Center Freiburg
Jan 22, 2019 05:15 PM Tuesday, January 22, 2019 | 17:15 h Event Bernstein Seminar | Simon Schultz | Imperial College London
Feb 12, 2019 05:15 PM Tuesday, February 12, 2019 Event Bernstein Seminar | Alessio Buccino | University of Oslo | Norway
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