Bernstein Center Freiburg

Bernstein Seminar

February 5, 2019
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Bernstein Seminar
SONJA GRÜN ►

Inst. of Neuroscience and Medicine & Inst. of Advanced Simulation | Research Center Jülich & Theoretical Systems Neurobiology | RWTH Aachen

Fine Temporal Spike Coordination in Relation to Behavior

Tuesday, February 5, 2019

17:15h

The talk is open to the public.
Guests are cordially invited!

Hosted by Ad Aertsen

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Bernstein Center Freiburg
Lecture Hall (ground floor)
Hansastr. 9a
79104 Freiburg


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Abstract

The computational role of spike coordination at millisecond precision among neurons in the cerebral cortex is hotly debated. Studies performed on data of limited size provided experimental evidence that low-order correlations occur in relation to behavior. Advances in electrophysiological technology to record from hundred(s) of neurons simultaneously provide the opportunity to observe coordinated spiking activity of larger number of neurons. We developed a method that combines data mining and statistical evaluation to search for significant synchronous spike patterns in massively parallel spike trains (Torre et al., 2013). The method solves the computational and multiple testing problems raised by the high dimensionality of the data.
Application of this method on simultaneous recordings of macaque monkey motor cortex engaged in an instructed-delay reachto-grasp task revealed specific patterns in relation to motor behavior (Torre et al, 2016). We were able to extend this method also to the detection and significance evaluation of spatio-temporal spike patterns, i.e. with temporal delay between the spikes (Yegenoglu et al, 2016; Quaglio et al, 2017; Quaglio, 2018). The spatio-temporal patterns we find are surprising: they involve only a relatively small number of neurons, whereas neurons are multiply part in different patterns. I will discuss possible implications and interpretations of the findings.

Literature

Synchronous Spike Patterns in Macaque Motor Cortex during an Instructed-Delay Reach-to-Grasp Task, The Journal of Neuroscience 2016, 36(32):8329-8340 (Link)

Torre E. et al: Quaglio et al: Detection and Evaluation of Spatio-Temporal Spike Patterns in Massively Parallel Spike Train Data with SPADE, Front Comput Neurosci. 2017, 11: 41. (Link)

Upcoming Talks

Feb 12, 2019
Alessio Buccino | University of Oslo
Feb 26, 2019
Mark Hübener | LMU München
Mar 5, 2019
Andreas Vlachos | Universität Freiburg

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