Bernstein Center Freiburg

Bernstein-CorTec-Award Talk

February 16, 2021
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Bernstein Seminar
KATHARINA HEINING ►

Institut für Mikrosystemtechnik IMTEK | Universität Freiburg

Beyond spikes and seizures: Detection and dynamics of epileptiform activity patterns

Tuesday, February 16, 2021

17:30 h

The talk is open to the public.
Guests are cordially invited!

Hosted by Jörn Rickert

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Zoom Meeting
Meeting ID and password will be sent with e-mail invitation
or contact Fiona Siegfried
Fiona Siegfried@bcf.uni-freiburg.de

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Abstract

In epilepsy, patients suffer from hypersynchronized brain activity. Such epileptiform activity (EA) can present itself in diverse patterns. Research thus far focused on the two most extreme versions, epileptiform spikes and seizures. Our goal was to better describe and understand the wide range of EA patterns in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy. We analyzed local field potentials recorded in vivo from the sclerotic hippocampus of chronically epileptic mice and developed a tool to automatically detect and classify EA patterns within a unified, data-based framework. The feature distributions of EA patterns suggested a continuum of EA in terms of spike load. We partitioned this continuum into bursts of high, medium, and low spike load. The temporal sequence of these burst patterns revealed macro-patterns: high-load clusters, transition phases, and background phases. In these phases, low-load bursts played a dual role. On the one hand, their rate was increased in transition phases surrounding high-load clusters. On the other hand, high rates of low-load bursts in background phases indicated reduced susceptibility to high-load bursts. This shows that low-load bursts could serve as a context-dependent marker for the susceptibility to high-load bursts and leads to the question, whether and how low-load bursts actively shape susceptibility dynamics.

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