Bernstein Center Freiburg

Bernstein Seminar

November 10, 2020
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Bernstein Seminar
HEIKO LUHMANN ►

Institute of Physiology | University Medical Center | Mainz

How electrical activity shapes the neonatal brain

Tuesday, November 10, 2020

17:15h

The talk is open to the public.
Guests are cordially invited!

Hosted by Uli Egert

vCal iCal

Zoom Meeting
Meeting ID and password will be sent with e-mail invitation
or contact Fiona Siegfried
Fiona Siegfried@bcf.uni-freiburg.de

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Abstract

At surprisingly early stages developing neuronal networks show spontaneous synchronized discharges. From EEG recordings in preterm human infants we know that so-called delta brush (spindle burst) activity can be already observed before the cerebral cortex has gained its typical six-layered structure. At this stage, a transient layer below the developing cortical plate, the so-called subplate, plays a pivotal role in the generation of early network activity and in the formation of thalamocortical and cortical networks (see recent review by Molnár, Luhmann, Kanold, Science 370, 16 October 2020). Since the cerebral cortex of rodents resembles in its structure the cortex of a preterm human infant, rodents are appropriate models to study the early development of cortical networks. Furthermore, spontaneous and evoked neuronal activity recorded with EEG in preterms share many similarities with the activity recorded with imaging and multi-electrode array techniques in newborn rodents. After giving a comparative overview into the early anatomical and physiological development of the cerebral cortex in humans and rodents, the following questions will be addressed in the online presentation: (i) What types of spontaneous and sensory evoked activity patterns can be recorded in the neocortex of newborn rodents? (ii) How is this early activity generated? (iii) What is the functional role of this early activity in shaping the developing cortical network and in controlling programmed cell death? (iv) What is the clinical relevance of these results obtained in rodents?

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