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Sadra Sadeh (University College London)

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"Modelling the emergence and consequences of feature-specific connectivity in mouse primary visual cortex" / Tuesday, July 14, 2015 17:15 h

  • Bernstein Seminar
When Jul 14, 2015
from 05:15 PM to 06:45 PM
Where Lecture Hall, Hansastr. 9a
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Bernstein Center Freiburg

Bernstein Seminar
Sadra Sadeh
University College London
Modelling the emergence and consequences of feature-specific connectivity in mouse primary visual cortex

Tuesday, July 14, 2015

17:15 h

Lecture Hall (ground floor)
Bernstein Center Freiburg
Hansastraße 9a
79104 Freiburg


At eye opening, excitatory neurons in mouse primary visual cortex show significant selectivity for certain orientations in the visual stimulus. Connections between these neurons are, however, independent of their respective orientation selectivity. Feature-specificity in wiring, where neurons with similar functional properties are more strongly connected together, develops only later, as the visual cortex maturates. In the first part of the talk, I present results on how this feature-specific connectivity may develop in large-scale networks of excitatory and inhibitory spiking neurons equipped with synaptic plasticity. In the second part, I discuss possible consequences of this for biologically realistic functional networks. One observation was that an excess of specific connectivity between excitatory neurons is not necessarily beneficial for sensory processing, as it leads to spectral instability, with pathologic correlations and even a decrease in signal amplification. I discuss some endogenous mechanisms the brain can employ to cope with this problem.
The talk is open to the public. Guests are cordially invited!
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