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You are here: Home Talks & Events Bernstein Seminar 2017 Philipp Schnepel, Max Delbrück Center for Molecular Medicine, Berlin | Hyperexcitability in Mouse Models of Autism-Spectrum Disorders

Philipp Schnepel, Max Delbrück Center for Molecular Medicine, Berlin | Hyperexcitability in Mouse Models of Autism-Spectrum Disorders

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Bernstein Seminar

What
  • Bernstein Seminar
When May 23, 2017
from 05:15 PM to 06:45 PM
Where BCF Lecture Hall, Hansastr. 9a
Contact Name
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Abstract

Autism Spectrum Disorder (ASD) is a genetically heterogeneous disorder for which the causal mechanism remains unidentified. It is hypothesized that a common pathology exists that is defined by an increased excitation-inhibition (E-I) ratio and hyperexcitability at the neural circuit level. Reports on deficits in interneuron number and of increased E-I ratio collectively suggest circuit excitability in ASD1-7 . To test this model, we are comparing local circuit physiology and sensory processing in primary somatosensory (S1) cortex across multiple ASD model mouse strains. S1 is a reasonable site to investigate ASD circuit dysfunction since 80-90% of ASD patients show sensory abnormalities including tactile hypersensitivity 8 . Here, we report initial results from three ASD strains: contactin associated protein-like 2 (Cntnap2), fragile X mental retardation 1 (Fmr1) and microdeletion on chromosome 16 (16p11.2) mice. Although whole-cell recordings in L2/3 of S1 slices indicate an increase in E-I-ratio, in vivo extracellular recordings show heterogeneous results across the different strains, suggesting that the hyperexcitability hypothesis needs to be revisited as a general mechanism for autism-spectrum disorders.

 

 

Literature

1Levy et al., Lancet 374, 1627 (2009). 2Markram and Markram, Front Hum Neurosci 4,224 (2010) 3Peñagarikano et al., Cell 147, 235 (2011). 4Bureau et al., Journal of Neuroscience, 28, 5178 (2008). 5Gogolla, et al. J Neurodev Disord1, 172 (2009). 6Rubenstein and Merzenich, Genes Brain Behav. 2, 255(2003). 7Yizhar et al. Nature 477, 171 (2011). 8. Geschwind, Annual Review of Medicine 60, 367 (2009).

 

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